Atenolol (versus unexposed) updated on 12-17-2024

Perinatal death

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14363
R56869		 Orbach, 2013 Perinatal death (NOS) 3rd trimester retrospective cohort (claims database) unexposed, disease free Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 0.33 [0.02;5.28] C 0/107   1,379/97,820 1,379 107
ref
Total 1 studies 0.33 [0.02;5.28] 1,379 107
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Orbach, 2013Orbach, 2013 0.33[0.02; 5.28]1,3791070%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.33[0.02; 5.28]1,379107 -NAOrbach, 2013 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.33[0.02; 5.28]1,379107 -NAOrbach, 2013 1 Tags Adjustment   - No  - No 0.33[0.02; 5.28]1,379107 -NAOrbach, 2013 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 0.33[0.02; 5.28]1,379107 -NAOrbach, 2013 1 All studiesAll studies 0.33[0.02; 5.28]1,379107 -NAOrbach, 2013 10.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.33[0.02; 5.28]1,379107 -NAOrbach, 2013 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Bellos (Perinatal death (Randomized controlle ...Bellos (Perinatal death (Randomized controlled trial and Cohort studies))) 1.75[0.77; 3.96]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 metaPregmetaPreg Out of scale0.33[0.02; 5.28]NaN%107----Orbach, 2013 10.510.01.0