Atenolol (versus unexposed) updated on 12-17-2024

Neonatal hypoglycemia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13801
R54111		 Bateman, 2016 Neonatal hypoglycemia (ICD-9 775.6) late pregnancy retrospective cohort (claims database) unexposed, sick Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 1.54 [0.99;2.40] 30/1,121   59/3,363 89 1,121
ref
S14349
R56788		 Darcie, 2004 Newborns with hypoglycemia (blood glycemia less than 40 mg/dL) late pregnancy prospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 4.64 [1.23;17.54] C 26/40   4/14 30 40
ref
Total 2 studies 2.22 [0.80;6.15] 119 1,161
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bateman, 2016Bateman, 2016 1.54[0.99; 2.40]891,12167%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Darcie, 2004Darcie, 2004 4.64[1.23; 17.54]304033%ROB confusion: seriousROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 58% 2.22[0.80; 6.15]1191,1610.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.22[0.80; 6.15]1191,16158%NABateman, 2016 Darcie, 2004 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.22[0.80; 6.15]1191,16158%NABateman, 2016 Darcie, 2004 2 Tags Adjustment   - No  - No 4.64[1.23; 17.54]3040 -NADarcie, 2004 1   - Yes  - Yes 1.54[0.99; 2.40]891,121 -NABateman, 2016 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 2.22[0.80; 6.15]1191,16158%NABateman, 2016 Darcie, 2004 2 All studiesAll studies 2.22[0.80; 6.15]1191,16158%NABateman, 2016 Darcie, 2004 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.22[0.80; 6.15]1191,16158%NABateman, 2016 Darcie, 2004 20.510.01.0