Atenolol (versus unexposed) updated on 12-17-2024

Late intrauterine deaths (> 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14298
R56331		 Lydakis, 1999 Stillbirth during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: Only chronic hypertension indication 1.17 [0.23;5.99] C 3/78   3/91 6 78
ref
Total 1 studies 1.17 [0.23;5.99] 6 78
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lydakis, 1999Lydakis, 1999 1.17[0.23; 5.99]6780%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.17[0.23; 5.99]678 -NALydakis, 1999 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.17[0.23; 5.99]678 -NALydakis, 1999 1 Tags Adjustment   - No  - No 1.17[0.23; 5.99]678 -NALydakis, 1999 1 Indications Antihypertensive   - Only chronic hypertension indication  - Only chronic hypertension indication 1.17[0.23; 5.99]678 -NALydakis, 1999 1 All studiesAll studies 1.17[0.23; 5.99]678 -NALydakis, 1999 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.17[0.23; 5.99]678 -NALydakis, 1999 10.510.01.0