Bisoprolol (versus unexposed) updated on 12-17-2024

Caesarean

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17245
R72167		 Vaclavik, 2024 Caesarean section during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 2.08 [1.72;2.52] -/175   -/252,856 - 175
ref
S14336
R56721		 Hoeltzenbein, 2018 C-section at least 1st trimester excluded prospective cohort unexposed, disease free Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 2.11 [1.58;2.81] C
excluded (exposition period) 		140/291   181/592 321 291
ref
Total 1 studies 2.08 [1.72;2.52] 0 175
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Vaclavik, 2024Vaclavik, 2024 2.08[1.72; 2.52]-1750%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: unclear0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.08[1.72; 2.52]-175 -NAVaclavik, 2024 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.08[1.72; 2.52]-175 -NAVaclavik, 2024 1 Tags Adjustment   - No  - No 2.08[1.72; 2.52]-175 -NAVaclavik, 2024 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 2.08[1.72; 2.52]-175 -NAVaclavik, 2024 1 All studiesAll studies 2.08[1.72; 2.52]-175 -NAVaclavik, 2024 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.08[1.72; 2.52]-175 -NAVaclavik, 2024 10.510.01.0