Bisoprolol (versus unexposed) updated on 12-17-2024

Small for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13512
R52197		 Fitton (Controls unexposed, disease free), 2020 Small for gestational age (birth weight below the 10th percentile) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, disease free excluded Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 2.67 [1.39;5.14]
excluded (control group) 		20/106   24,121/250,693 24,141 106
ref
S14421
R57249		 Fitton (Controls unexposed, sick), 2020 Small for gestational age (birth weight below the 10th percentile) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 1.52 [0.93;2.48] C 20/106   1,059/7,971 1,079 106
ref
S14075
R55409		 Tanaka, 2016 Fetal growth restriction (considered equivalent to light for gestational age, birth weight <10th percentile for gestational age) during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) 3.06 [0.14;68.71] C 0/5   3/100 3 5
ref
Total 2 studies 1.54 [0.95;2.51] 1,082 111
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Fitton (Controls unexposed, sick), 2020Fitton, 2020 1 1.52[0.93; 2.48]1,07910698%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: moderateROB mesure: moderateROB reporting: moderate Tanaka, 2016Tanaka, 2016 3.06[0.14; 68.71]352%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.54[0.95; 2.51]1,0821110.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.54[0.95; 2.51]1,0821110%NAFitton (Controls unexposed, sick), 2020 Tanaka, 2016 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.54[0.95; 2.51]1,0821110%NAFitton (Controls unexposed, sick), 2020 Tanaka, 2016 2 Tags Adjustment   - No  - No 1.54[0.95; 2.51]1,0821110%NAFitton (Controls unexposed, sick), 2020 Tanaka, 2016 2 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 1.52[0.93; 2.48]1,079106 -NAFitton (Controls unexposed, sick), 2020 1   - Only cardiac indications other than ...  - Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) 3.06[0.14; 68.71]35 -NATanaka, 2016 1 All studiesAll studies 1.54[0.95; 2.51]1,0821110%NAFitton (Controls unexposed, sick), 2020 Tanaka, 2016 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 13512

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.67[1.39; 5.13]24,141106 -NAFitton (Controls unexposed, disease free), 2020 1 unexposed, sick controlsunexposed, sick controls 1.54[0.95; 2.51]1,0821110%NAFitton (Controls unexposed, sick), 2020 Tanaka, 2016 20.510.01.0