Amlodipine (versus unexposed)

Preeclampsia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14425
R57258		 Mito, 2019 Superimposed preeclampsia at least 1st trimester retrospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: Only chronic hypertension indication 0.91 [0.45;1.85] C 15/48   43/129 58 48
ref
Total 1 studies 0.91 [0.45;1.85] 58 48
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Mito, 2019Mito, 2019 0.91[0.45; 1.85]58480%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.91[0.45; 1.85]5848 -NAMito, 2019 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.91[0.45; 1.85]5848 -NAMito, 2019 1 Tags Adjustment   - No  - No 0.91[0.45; 1.85]5848 -NAMito, 2019 1 Indications Antihypertensive   - Only chronic hypertension indication  - Only chronic hypertension indication 0.91[0.45; 1.85]5848 -NAMito, 2019 1 All studiesAll studies 0.91[0.45; 1.85]5848 -NAMito, 2019 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.91[0.45; 1.85]5848 -NAMito, 2019 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Bellos (Preeclampsia (Randomized controlled t ...Bellos (Preeclampsia (Randomized controlled trial and Cohort studies)) 0.84[0.30; 2.33]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 Bellos (Preeclampsia (Randomized controlled t ...Bellos (Preeclampsia (Randomized controlled trial only)) 0.70[0.09; 5.45]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 metaPregmetaPreg 0.91[0.45; 1.85]NaN%48----Mito, 2019 10.510.01.0