Amlodipine (versus unexposed)

Caesarean

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17247
R72175		 Vaclavik, 2024 Caesarean section during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 2.82 [2.35;3.38] -/221   -/252,856 - 221
ref
Total 1 studies 2.82 [2.35;3.38] 0 221
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Vaclavik, 2024Vaclavik, 2024 2.82[2.35; 3.38]-2210%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: unclear0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.82[2.35; 3.38]-221 -NAVaclavik, 2024 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.82[2.35; 3.38]-221 -NAVaclavik, 2024 1 Tags Adjustment   - No  - No 2.82[2.35; 3.38]-221 -NAVaclavik, 2024 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 2.82[2.35; 3.38]-221 -NAVaclavik, 2024 1 All studiesAll studies 2.82[2.35; 3.38]-221 -NAVaclavik, 2024 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.82[2.35; 3.38]-221 -NAVaclavik, 2024 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Bellos (Cesarean delivery (Randomized control ...Bellos (Cesarean delivery (Randomized controlled trial and Cohort studies)) 1.35[0.38; 4.80]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 Bellos (Cesarean delivery (Randomized control ...Bellos (Cesarean delivery (Randomized controlled trial only)) 1.35[0.38; 4.80]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 metaPregmetaPreg 2.82[2.35; 3.38]NaN%221----Vaclavik, 2024 10.510.01.0