Amlodipine (versus unexposed)

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17247
R72176		 Vaclavik, 2024 Preterm delivery during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 3.25 [2.58;4.09] -/90   -/71,860 - 90
ref
S14425
R57260		 Mito, 2019 Preterm birth (<37 wks) at least 1st trimester retrospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: Only chronic hypertension indication 0.56 [0.26;1.24] C 10/48   41/129 51 48
ref
S13989
R54931		 Weber-Schoendorfer, 2008 Preterm children (<37 weeks) at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 4.19 [1.72;10.22] C 7/31   47/722 54 31
ref
Total 3 studies 2.01 [0.67;6.00] 105 169
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Vaclavik, 2024Vaclavik, 2024 3.25[2.58; 4.09]-9038%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: unclear Mito, 2019Mito, 2019 0.56[0.26; 1.24]514832%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Weber-Schoendorfer, 2008Weber-Schoendorfer, 2008 4.19[1.72; 10.22]543130%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: unclearROB reporting: moderate Total (3 studies) I2 = 89% 2.01[0.67; 6.00]1051690.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.01[0.67; 6.00]10516989%NAVaclavik, 2024 Mito, 2019 Weber-Schoendorfer, 2008 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.30[2.64; 4.13]541210%NAVaclavik, 2024 Weber-Schoendorfer, 2008 2 unexposed, sickunexposed, sick 0.56[0.26; 1.24]5148 -NAMito, 2019 1 Tags Adjustment   - No  - No 2.01[0.67; 6.00]10516989%NAVaclavik, 2024 Mito, 2019 Weber-Schoendorfer, 2008 3 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 3.30[2.64; 4.13]541210%NAVaclavik, 2024 Weber-Schoendorfer, 2008 2   - Only chronic hypertension indication  - Only chronic hypertension indication 0.56[0.26; 1.24]5148 -NAMito, 2019 1 All studiesAll studies 2.01[0.67; 6.00]10516989%NAVaclavik, 2024 Mito, 2019 Weber-Schoendorfer, 2008 30.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.30[2.64; 4.13]541210%NAVaclavik, 2024 Weber-Schoendorfer, 2008 2 unexposed, sick controlsunexposed, sick controls 0.56[0.26; 1.24]5148 -NAMito, 2019 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Bellos (Preterm birth (Randomized controlled ...Bellos (Preterm birth (Randomized controlled trial and Cohort studies)) 0.75[0.22; 2.51]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 Bellos (Preterm birth (Randomized controlled ...Bellos (Preterm birth (Randomized controlled trial only)) 1.50[0.19; 11.56]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 metaPregmetaPreg 2.01[0.67; 6.00]89%169----Vaclavik, 2024 Mito, 2019 Weber-Schoendorfer, 2008 30.510.01.0