Metoprolol (versus unexposed) updated on 12-17-2024

Low Apgar score (< 7) (at 1 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13913
R54431		 Duan, 2018 Low APGAR score (<7) at 1 min during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 1.33 [0.84;2.11] C 19/324   16,755/374,391 16,774 324
ref
Total 1 studies 1.33 [0.84;2.11] 16,774 324
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Duan, 2018Duan, 2018 1.33[0.84; 2.11]16,7743240%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.33[0.84; 2.11]16,774324 -NADuan, 2018 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.33[0.84; 2.11]16,774324 -NADuan, 2018 1 Tags Adjustment   - No  - No 1.33[0.84; 2.11]16,774324 -NADuan, 2018 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 1.33[0.84; 2.11]16,774324 -NADuan, 2018 1 All studiesAll studies 1.33[0.84; 2.11]16,774324 -NADuan, 2018 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.33[0.84; 2.11]16,774324 -NADuan, 2018 10.510.01.0