Metoprolol (versus unexposed) updated on 12-17-2024

Neonatal hypoglycemia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13800
R54109		 Bateman, 2016 Neonatal hypoglycemia (ICD-9 775.6) late pregnancy retrospective cohort (claims database) unexposed, sick Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 1.64 [1.15;2.33] 49/1,484   91/4,452 140 1,484
ref
Total 1 studies 1.64 [1.15;2.33] 140 1,484
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bateman, 2016Bateman, 2016 1.64[1.15; 2.33]1401,4840%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.64[1.15; 2.33]1401,484 -NABateman, 2016 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.64[1.15; 2.33]1401,484 -NABateman, 2016 1 Tags Adjustment   - Yes  - Yes 1.64[1.15; 2.33]1401,484 -NABateman, 2016 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 1.64[1.15; 2.33]1401,484 -NABateman, 2016 1 All studiesAll studies 1.64[1.15; 2.33]1401,484 -NABateman, 2016 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.64[1.15; 2.33]1401,484 -NABateman, 2016 10.510.01.0