Metoprolol (versus unexposed) updated on 12-17-2024

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17477
R73484		 Delteil, 2024 Major congenital malformations at least 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Indications Antihypertensive: Only chronic indication (hypertension or cardiac) 3.71 [1.33;10.34] C 4/47   4,054/165,775 4,058 47
ref
Total 1 studies 3.71 [1.33;10.34] 4,058 47
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Delteil, 2024Delteil, 2024 3.71[1.33; 10.34]4,058470%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.71[1.33; 10.34]4,05847 -NADelteil, 2024 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.71[1.33; 10.34]4,05847 -NADelteil, 2024 1 Tags Adjustment   - No  - No 3.71[1.33; 10.34]4,05847 -NADelteil, 2024 1 Indications Antihypertensive   - Only chronic indication (hypertensi ...  - Only chronic indication (hypertension or cardiac) 3.71[1.33; 10.34]4,05847 -NADelteil, 2024 1 All studiesAll studies 3.71[1.33; 10.34]4,05847 -NADelteil, 2024 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.71[1.33; 10.34]4,05847 -NADelteil, 2024 10.510.01.0