Metoprolol (versus unexposed) updated on 12-17-2024

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17157
R71958		 Vaclavik, 2024 Low birth weight during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 2.55 [2.33;2.79] -/546   -/66,393 - 546
ref
S13913
R54429		 Duan, 2018 Low birth weight (birth weight <2500g) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 2.80 [2.03;3.86] C 43/324   19,393/374,391 19,436 324
ref
Total 2 studies 2.57 [2.35;2.80] 19,436 870
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Vaclavik, 2024Vaclavik, 2024 2.55[2.33; 2.79]-54693%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: unclear Duan, 2018Duan, 2018 2.80[2.03; 3.86]19,4363247%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 2.57[2.35; 2.80]19,4368700.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.57[2.35; 2.80]19,4368700%NAVaclavik, 2024 Duan, 2018 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.57[2.35; 2.80]19,4368700%NAVaclavik, 2024 Duan, 2018 2 Tags Adjustment   - No  - No 2.57[2.35; 2.80]19,4368700%NAVaclavik, 2024 Duan, 2018 2 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 2.57[2.35; 2.80]19,4368700%NAVaclavik, 2024 Duan, 2018 2 All studiesAll studies 2.57[2.35; 2.80]19,4368700%NAVaclavik, 2024 Duan, 2018 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.57[2.35; 2.80]19,4368700%NAVaclavik, 2024 Duan, 2018 20.510.01.0