Valsartan (versus unexposed) updated on 03-11-2025

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14151
R56258		 Hoeltzenbein, 2018 Major birth defects early pregnancy prospective cohort unexposed, disease free Adjustment: No Indications Antihypertensive: Only chronic hypertension indication Matched 5.00 [1.57;15.93] C 4/30   17/570 21 30
ref
Total 1 studies 5.00 [1.57;15.93] 21 30
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Hoeltzenbein, 2018Hoeltzenbein, 2018 5.00[1.57; 15.93]21300%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: unclearROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 5.00[1.57; 15.93]2130 -NAHoeltzenbein, 2018 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 5.00[1.57; 15.93]2130 -NAHoeltzenbein, 2018 1 Tags Adjustment   - No  - No 5.00[1.57; 15.93]2130 -NAHoeltzenbein, 2018 1 Indications Antihypertensive   - Only chronic hypertension indication  - Only chronic hypertension indication 5.00[1.57; 15.93]2130 -NAHoeltzenbein, 2018 1 MatchedMatched 5.00[1.57; 15.93]2130 -NAHoeltzenbein, 2018 1 All studiesAll studies 5.00[1.57; 15.93]2130 -NAHoeltzenbein, 2018 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 5.00[1.57; 15.93]2130 -NAHoeltzenbein, 2018 10.510.01.0