Propranolol (versus unexposed) updated on 12-17-2024

Neural Tube Defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13916
R54490		 Bergman, 2018 Neural tube defects 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 0.45 [0.06;3.29] C 1/30   3,888/54,457 3,889 30
ref
Total 1 studies 0.45 [0.06;3.29] 3,889 30
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bergman, 2018Bergman, 2018 0.45[0.06; 3.29]3,889300%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.45[0.06; 3.29]3,88930 -NABergman, 2018 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.45[0.06; 3.29]3,88930 -NABergman, 2018 1 Tags Adjustment   - Yes  - Yes 0.45[0.06; 3.29]3,88930 -NABergman, 2018 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 0.45[0.06; 3.29]3,88930 -NABergman, 2018 1 All studiesAll studies 0.45[0.06; 3.29]3,88930 -NABergman, 2018 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.45[0.06; 3.29]3,88930 -NABergman, 2018 10.510.01.0