Beta-blockers (Ocular route only) (versus unexposed) - Medication and Pregnancy KB

Beta-blockers (Ocular route only) (versus unexposed) updated on 12-17-2024

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S17249 R72191	Kaufman - Beta-blockers, 2024	Miscarriage (pregnancy loss at 20-weeks gestation or earlier)	during pregnancy (anytime or not specified)	retrospective cohort	unexposed, sick	Adjustment: No	1.49 [0.16;14.19] ^C	4/55 1/20	5	55		ref
S14054 R55579	Pellegrino - Timolol, 2018	Miscarriage	throughout pregnancy	prospective cohort	unexposed, disease free	Adjustment: No	2.21 [0.57;8.61] ^C	3/27 10/187	13	27		ref
					Total	2 studies	1.99 [0.62;6.38]		18	82
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded