Timolol (Ocular route only) (versus unexposed) updated on 12-17-2024

Neonatal medical care

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14292
R56226		 Pellegrino, 2018 Neonatal Respiratory complication (apnea, cyanosis, grunting, inspiratory stridor, nasal flaring, poor feeding, and tachypnea (more than 60 breaths per minute)) throughout pregnancy prospective cohort unexposed, disease free Adjustment: No 8.24 [0.50;136.65] C 1/22   1/174 2 22
ref
Total 1 studies 8.24 [0.50;136.65] 2 22
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Pellegrino, 2018Pellegrino, 2018 8.24[0.50; 136.65]2220%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: criticalROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 8.24[0.50; 136.65]222 -NAPellegrino, 2018 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 8.24[0.50; 136.65]222 -NAPellegrino, 2018 1 Tags Adjustment   - No  - No 8.24[0.50; 136.65]222 -NAPellegrino, 2018 1 All studiesAll studies 8.24[0.50; 136.65]222 -NAPellegrino, 2018 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 8.24[0.50; 136.65]222 -NAPellegrino, 2018 10.510.01.0