Timolol (Ocular route only) (versus unexposed) updated on 12-17-2024

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14292
R56304		 Pellegrino, 2018 Major Malformations throughout pregnancy prospective cohort unexposed, disease free Adjustment: No 0.71 [0.04;13.34] C 0/22   5/174 5 22
ref
Total 1 studies 0.71 [0.04;13.34] 5 22
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Pellegrino, 2018Pellegrino, 2018 0.71[0.04; 13.34]5220%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: unclearROB mesure: criticalROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.71[0.04; 13.34]522 -NAPellegrino, 2018 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.71[0.04; 13.34]522 -NAPellegrino, 2018 1 Tags Adjustment   - No  - No 0.71[0.04; 13.34]522 -NAPellegrino, 2018 1 All studiesAll studies 0.71[0.04; 13.34]522 -NAPellegrino, 2018 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.71[0.04; 13.34]522 -NAPellegrino, 2018 10.510.01.0