Timolol (Ocular route only) (versus unexposed) updated on 12-17-2024

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14292
R56225		 Pellegrino, 2018 Low Birth Weight (< 2500g) throughout pregnancy prospective cohort unexposed, disease free Adjustment: No 1.06 [0.23;4.98] C 2/22   15/174 17 22
ref
Total 1 studies 1.06 [0.23;4.98] 17 22
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Pellegrino, 2018Pellegrino, 2018 1.06[0.23; 4.98]17220%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: criticalROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.06[0.23; 4.98]1722 -NAPellegrino, 2018 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.06[0.23; 4.98]1722 -NAPellegrino, 2018 1 Tags Adjustment   - No  - No 1.06[0.23; 4.98]1722 -NAPellegrino, 2018 1 All studiesAll studies 1.06[0.23; 4.98]1722 -NAPellegrino, 2018 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.06[0.23; 4.98]1722 -NAPellegrino, 2018 10.510.01.0