Pindolol (versus unexposed) updated on 12-17-2024

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14384
R57059		 Rosenfeld, 1986 Low birth weight (< 2500 g) during pregnancy (anytime or not specified) randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Antihypertensive: All hypertensions, any indications or not specified 0.93 [0.28;3.06] C 9/23   9/22 18 23
ref
Total 1 studies 0.93 [0.28;3.06] 18 23
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Rosenfeld, 1986Rosenfeld, 1986 0.93[0.28; 3.06]18230%ROB confusion: lowROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0 RCTRCT 0.93[0.28; 3.06]1823 -NARosenfeld, 1986 1 Type of controls unexposed, sickunexposed, sick 0.93[0.28; 3.06]1823 -NARosenfeld, 1986 1 Tags Adjustment   - Randomisation  - Randomisation 0.93[0.28; 3.06]1823 -NARosenfeld, 1986 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 0.93[0.28; 3.06]1823 -NARosenfeld, 1986 1 All studiesAll studies 0.93[0.28; 3.06]1823 -NARosenfeld, 1986 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.93[0.28; 3.06]1823 -NARosenfeld, 1986 10.510.01.0