Thiouracil, propylthiouracil, benzylthiouracil

Digestive system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3366
R6157		 Seo (control exposed to MMI), 2018 Other digestive system (Q38–Q45) 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 0.49 [0.25;0.95] C
excluded (control group) 		48/9,930   11/1,120 59 9,930
ref
S3367
R6169		 Seo (control unexposed, NOS), 2018 Other digestive system (Q38–Q45) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.15 [0.87;1.53] 48/9,930   11,991/2,872,109 12,039 9,930
ref
S3340
R5758		 Andersen 2017 (control exposed to MMI/CMZ), 2017 Digestive system early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 3.75 [0.18;78.59] C
excluded (control group) 		2/218   0/162 2 218
ref
S3339
R5741		 Andersen 2017 (control unexposed, disease free), 2017 Digestive system early pregnancy population based cohort retrospective unexposed, disease free excluded Adjustment: No 3.57 [0.89;14.38] C
excluded (control group) 		2/218   1,765/682,343 1,767 218
ref
S3338
R5724		 Andersen 2017 (control unexposed, sick), 2017 Digestive system early pregnancy population based cohort retrospective unexposed, sick Adjustment: No 3.58 [0.65;19.67] C 2/218   4/1,551 6 218
ref
Total 2 studies 1.47 [0.59;3.67] 12,045 10,148
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Seo (control unexposed, NOS), 2018Seo, 2018 1 1.15[0.87; 1.53]12,0399,93078%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Andersen 2017 (control unexposed, sick), 2017Andersen 2017, 2017 2 3.58[0.65; 19.67]621822%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 40% 1.47[0.59; 3.67]12,04510,1480.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, NOS; 2: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.47[0.59; 3.67]12,04510,14840%NASeo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, sick), 2017 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.15[0.87; 1.53]12,0399,930 -NASeo (control unexposed, NOS), 2018 1 unexposed, sickunexposed, sick 3.58[0.65; 19.67]6218 -NAAndersen 2017 (control unexposed, sick), 2017 1 Tags Adjustment   - No  - No 3.58[0.65; 19.67]6218 -NAAndersen 2017 (control unexposed, sick), 2017 1   - Yes  - Yes 1.15[0.87; 1.53]12,0399,930 -NASeo (control unexposed, NOS), 2018 1 All studiesAll studies 1.47[0.59; 3.67]12,04510,14840%NASeo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, sick), 2017 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3340, 3339, 3366

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.64[0.59; 4.57]13,80610,14859%NASeo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, disease free), 2017 2 unexposed, sick controlsunexposed, sick controls 3.58[0.65; 19.67]6218 -NAAndersen 2017 (control unexposed, sick), 2017 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.77[0.15; 4.05]6110,14839%NASeo (control exposed to MMI), 2018 Andersen 2017 (control exposed to MMI/CMZ), 2017 20.510.01.0