Thiouracil, propylthiouracil, benzylthiouracil

Late intrauterine deaths (> 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3374
R6202		 Rosenfeld, 2009 Stillbirth during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No 1.42 [0.07;27.65] C 0/115   3/1,141 3 115
ref
S3439
R6390		 Davis, 1989 Stillbirth during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 0.04 [0.01;0.29] C 2/52   4/8 6 52
ref
Total 2 studies 0.20 [0.01;6.47] 9 167
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Rosenfeld, 2009Rosenfeld, 2009 1.42[0.07; 27.65]311545%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: criticalROB reporting: moderate Davis, 1989Davis, 1989 0.04[0.01; 0.29]65255%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: unclear Total (2 studies) I2 = 74% 0.20[0.01; 6.47]91670.05.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.20[0.01; 6.47]916774%NARosenfeld, 2009 Davis, 1989 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.42[0.07; 27.65]3115 -NARosenfeld, 2009 1 unexposed, sickunexposed, sick 0.04[0.01; 0.29]652 -NADavis, 1989 1 Tags Adjustment   - No  - No 0.20[0.01; 6.47]916774%NARosenfeld, 2009 Davis, 1989 2 All studiesAll studies 0.20[0.01; 6.47]916774%NARosenfeld, 2009 Davis, 1989 20.05.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.42[0.07; 27.65]3115 -NARosenfeld, 2009 1 unexposed, sick controlsunexposed, sick controls Out of scale0.04[0.01; 0.29]652 -NADavis, 1989 10.510.01.0