Interferon beta 1b (IFN-beta1b)

Intrauterine deaths (as a whole or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3706
R7909		 Nguyen (control exposed to Glatiramer), 2019 Spontaneous abortion/Miscarriage (NOS) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No 0.69 [0.18;2.65] C
excluded (control group) 		3/52   9/110 12 52
ref
S3708
R7915		 Nguyen (control unexposed, sick), 2019 Spontaneous abortion/Miscarriage (NOS) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 0.87 [0.26;2.90] C 3/52   50/763 53 52
ref
S3699
R7882		 Weber-Schoendorfer (control exposed to Glatiramer), 2009 Miscarriage at least 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No 9.62 [1.01;91.16] C
excluded (control group) 		5/18   1/26 6 18
ref
S3701
R7890		 Weber-Schoendorfer (control unexposed, disease free), 2009 Miscarriage at least 1st trimester prospective cohort unexposed, disease free excluded Adjustment: No 3.84 [1.35;10.93] C
excluded (control group) 		5/18   138/1,515 143 18
ref
S3703
R7898		 Weber-Schoendorfer (control unexposed, sick), 2009 Miscarriage at least 1st trimester prospective cohort unexposed, sick Adjustment: No 3.53 [0.93;13.36] C 5/18   6/61 11 18
ref
Total 2 studies 1.70 [0.43;6.67] 64 70
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Nguyen (control unexposed, sick), 2019Nguyen, 2019 1 0.87[0.26; 2.90]535252%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Weber-Schoendorfer (control unexposed, sick), 2009Weber-Schoendorfer, 2009 2 3.53[0.93; 13.36]111848%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 57% 1.70[0.43; 6.67]64700.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick; 2: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.70[0.43; 6.67]647057%NANguyen (control unexposed, sick), 2019 Weber-Schoendorfer (control unexposed, sick), 2009 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.70[0.43; 6.67]647057%NANguyen (control unexposed, sick), 2019 Weber-Schoendorfer (control unexposed, sick), 2009 2 Tags Adjustment   - No  - No 1.70[0.43; 6.67]647057%NANguyen (control unexposed, sick), 2019 Weber-Schoendorfer (control unexposed, sick), 2009 2 All studiesAll studies 1.70[0.43; 6.67]647057%NANguyen (control unexposed, sick), 2019 Weber-Schoendorfer (control unexposed, sick), 2009 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3699, 3701, 3706

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.84[1.35; 10.93]14318 -NAWeber-Schoendorfer (control unexposed, disease free), 2009 1 unexposed, sick controlsunexposed, sick controls 1.70[0.43; 6.67]647057%NANguyen (control unexposed, sick), 2019 Weber-Schoendorfer (control unexposed, sick), 2009 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.19[0.17; 28.54]187074%NANguyen (control exposed to Glatiramer), 2019 Weber-Schoendorfer (control exposed to Glatiramer), 2009 20.510.01.0