Interferon beta 1b (IFN-beta1b)

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3706
R7908
Nguyen (control exposed to Glatiramer), 2019 Pre-term (<37 weeks) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No 0.86 [0.37;1.99] C
excluded (control group)
10/45   24/96 34 45
ref
S3708
R7914
Nguyen (control unexposed, sick), 2019 Pre-term (<37 weeks) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 0.79 [0.38;1.63] C 10/45   182/686 192 45
ref
S3710
R7938
Fragoso a (control exposed to Glatiramer), 2013 Prematurity (NOS) during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick excluded Adjustment: No 9.50 [0.77;117.91] C
excluded (control group)
2/10   1/39 3 10
ref
S3712
R7974
Fragoso a (control unexposed, sick), 2013 Prematurity (NOS) during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 7.67 [1.11;52.80] C 2/10   3/95 5 10
ref
S3699
R7883
Weber-Schoendorfer (control exposed to Glatiramer), 2009 Preterm births at least 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No 2.00 [0.11;34.82] C
excluded (control group)
1/13   1/25 2 13
ref
S3701
R7891
Weber-Schoendorfer (control unexposed, disease free), 2009 Preterm births at least 1st trimester prospective cohort unexposed, disease free excluded Adjustment: No 1.19 [0.15;9.27] C
excluded (control group)
1/13   90/1,377 91 13
ref
S3703
R7899
Weber-Schoendorfer (control unexposed, sick), 2009 Preterm births at least 1st trimester prospective cohort unexposed, sick Adjustment: No 0.49 [0.06;4.30] C 1/13   8/55 9 13
ref
Total 3 studies 1.32 [0.31;5.56] 206 68
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Nguyen (control unexposed, sick), 2019Nguyen, 2019 1 0.79[0.38; 1.63]1924548%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Fragoso a (control unexposed, sick), 2013Fragoso a, 2013 2 7.67[1.11; 52.80]51028%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Weber-Schoendorfer (control unexposed, sick), 2009Weber-Schoendorfer, 2009 3 0.49[0.06; 4.30]91324%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 61% 1.32[0.31; 5.56]206680.220.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick; 2: control unexposed, sick; 3: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.32[0.31; 5.56]2066861%NANguyen (control unexposed, sick), 2019 Fragoso a (control unexposed, sick), 2013 Weber-Schoendorfer (control unexposed, sick), 2009 3 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.32[0.31; 5.56]2066861%NANguyen (control unexposed, sick), 2019 Fragoso a (control unexposed, sick), 2013 Weber-Schoendorfer (control unexposed, sick), 2009 3 Tags Adjustment   - No  - No 1.32[0.31; 5.56]2066861%NANguyen (control unexposed, sick), 2019 Fragoso a (control unexposed, sick), 2013 Weber-Schoendorfer (control unexposed, sick), 2009 3 All studiesAll studies 1.32[0.31; 5.56]2066861%NANguyen (control unexposed, sick), 2019 Fragoso a (control unexposed, sick), 2013 Weber-Schoendorfer (control unexposed, sick), 2009 30.220.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3699, 3701, 3710, 3706

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.19[0.15; 9.27]9113 -NAWeber-Schoendorfer (control unexposed, disease free), 2009 1 unexposed, sick controlsunexposed, sick controls 1.32[0.31; 5.56]2066861%NANguyen (control unexposed, sick), 2019 Fragoso a (control unexposed, sick), 2013 Weber-Schoendorfer (control unexposed, sick), 2009 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.71[0.42; 7.05]396840%NANguyen (control exposed to Glatiramer), 2019 Fragoso a (control exposed to Glatiramer), 2013 Weber-Schoendorfer (control exposed to Glatiramer), 2009 30.510.01.0