Carbimazole, Thiamazole (Methimazole)

Nervous system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3364
R6128		 Seo (control exposed to PTU), 2018 Nervous system (Q00–Q07) 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 2.83 [1.21;6.65] C
excluded (control group) 		7/1,120   22/9,930 29 1,120
ref
S3365
R6140		 Seo (control unexposed, NOS), 2018 Nervous system (Q00–Q07) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 2.92 [1.39;6.14] 7/1,120   5,843/2,872,109 5,850 1,120
ref
S3337
R5701		 Andersen 2017 (control exposed to PTU), 2017 Nervous system early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.45 [0.02;11.04] C
excluded (control group) 		0/162   1/218 1 162
ref
S3335
R5666		 Andersen 2017 (control unexposed, disease free), 2017 Nervous system early pregnancy population based cohort retrospective unexposed, disease free excluded Adjustment: No 2.07 [0.13;33.28] C
excluded (control group) 		0/162   1,018/682,343 1,018 162
ref
S3336
R5680		 Andersen 2017 (control unexposed, sick), 2017 Nervous system early pregnancy population based cohort retrospective unexposed, sick Adjustment: No 1.92 [0.09;40.12] C 0/162   2/1,551 2 162
ref
Total 2 studies 2.85 [1.39;5.87] 5,852 1,282
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Seo (control unexposed, NOS), 2018Seo, 2018 1 2.92[1.39; 6.14]5,8501,12094%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Andersen 2017 (control unexposed, sick), 2017Andersen 2017, 2017 2 1.92[0.09; 40.12]21626%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 2.85[1.39; 5.87]5,8521,2820.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, NOS; 2: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.85[1.39; 5.87]5,8521,2820%NASeo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, sick), 2017 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.92[1.39; 6.14]5,8501,120 -NASeo (control unexposed, NOS), 2018 1 unexposed, sickunexposed, sick 1.92[0.09; 40.12]2162 -NAAndersen 2017 (control unexposed, sick), 2017 1 Tags Adjustment   - No  - No 1.92[0.09; 40.12]2162 -NAAndersen 2017 (control unexposed, sick), 2017 1   - Yes  - Yes 2.92[1.39; 6.14]5,8501,120 -NASeo (control unexposed, NOS), 2018 1 All studiesAll studies 2.85[1.39; 5.87]5,8521,2820%NASeo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, sick), 2017 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3337, 3335, 3364

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.85[1.39; 5.85]6,8681,2820%NASeo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, disease free), 2017 2 unexposed, sick controlsunexposed, sick controls 1.92[0.09; 40.12]2162 -NAAndersen 2017 (control unexposed, sick), 2017 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.21[0.64; 7.61]301,28216%NASeo (control exposed to PTU), 2018 Andersen 2017 (control exposed to PTU), 2017 20.510.01.0