Carbimazole, Thiamazole (Methimazole)

Genital anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3447
R6444
Andersen (control exposed to PTU), 2019 Genital organs (Q50-56) early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.94 [0.41;2.16] C
excluded (control group)
15/1,574   9/889 24 1,574
ref
S3446
R6429
Andersen (control unexposed, disease free), 2019 Genital organs (Q50-56) early pregnancy population based cohort retrospective unexposed, disease free Adjustment: No 0.91 [0.54;1.51] C 15/1,574   12,182/1,159,181 12,197 1,574
ref
S3364
R6134
Seo (control exposed to PTU), 2018 Genital organs (Q50–Q56) 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 1.02 [0.46;2.23] C
excluded (control group)
7/1,120   61/9,930 68 1,120
ref
S3365
R6146
Seo (control unexposed, NOS), 2018 Genital organs (Q50–Q56) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.22 [0.58;2.58] 7/1,120   13,532/2,872,109 13,539 1,120
ref
S3337
R5708
Andersen 2017 (control exposed to PTU), 2017 Genital organs early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 3.44 [0.66;17.96] C
excluded (control group)
5/162   2/218 7 162
ref
S3335
R5673
Andersen 2017 (control unexposed, disease free), 2017 Genital organs early pregnancy population based cohort retrospective unexposed, disease free excluded Adjustment: No 2.28 [0.93;5.55] C
excluded (control group)
5/162   9,415/682,343 9,420 162
ref
S3336
R5687
Andersen 2017 (control unexposed, sick), 2017 Genital organs early pregnancy population based cohort retrospective unexposed, sick Adjustment: No 1.94 [0.73;5.15] C 5/162   25/1,551 30 162
ref
S3386
R6303
Korelitz (control exposed to PTU), 2013 Congenital anomalies of genital organs 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 0.40 [0.02;6.89] C
excluded (control group)
0/108   10/915 10 108
ref
S3384
R6287
Korelitz (control unexposed, disease free), 2013 Congenital anomalies of genital organs 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 0.47 [0.03;7.64] C
excluded (control group)
0/108   6,161/634,858 6,161 108
ref
S3385
R6295
Korelitz (control unexposed, sick), 2013 Congenital anomalies of genital organs 3 months (or more) before pregnancy or during pregnancy excluded retrospective cohort (claims database) unexposed, sick Adjustment: No 0.49 [0.03;8.05] C
excluded (exposition period)
0/108   30/3,236 30 108
ref
Total 3 studies 1.11 [0.75;1.63] 25,766 2,856
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Andersen (control unexposed, disease free), 2019Andersen, 2019 1 0.91[0.54; 1.51]12,1971,57458%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Seo (control unexposed, NOS), 2018Seo, 2018 2 1.22[0.58; 2.58]13,5391,12027%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Andersen 2017 (control unexposed, sick), 2017Andersen 2017, 2017 3 1.94[0.73; 5.15]3016216%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 1.11[0.75; 1.63]25,7662,8560.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, disease free; 2: control unexposed, NOS; 3: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.11[0.75; 1.63]25,7662,8560%NAAndersen (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, sick), 2017 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.00[0.65; 1.52]25,7362,6940%NAAndersen (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 2 unexposed, sickunexposed, sick 1.94[0.73; 5.15]30162 -NAAndersen 2017 (control unexposed, sick), 2017 1 Tags Adjustment   - No  - No 1.18[0.58; 2.40]12,2271,73646%NAAndersen (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, sick), 2017 2   - Yes  - Yes 1.22[0.58; 2.57]13,5391,120 -NASeo (control unexposed, NOS), 2018 1 All studiesAll studies 1.11[0.75; 1.63]25,7662,8560%NAAndersen (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, sick), 2017 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3386, 3384, 3337, 3335, 3364, 3447

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.23[0.75; 2.02]35,1562,85636%NAAndersen (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, disease free), 2017 3 unexposed, sick controlsunexposed, sick controls 1.94[0.73; 5.15]30162 -NAAndersen 2017 (control unexposed, sick), 2017 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.12[0.65; 1.92]992,8560%NAAndersen (control exposed to PTU), 2019 Seo (control exposed to PTU), 2018 Andersen 2017 (control exposed to PTU), 2017 30.510.01.0