Thiouracil, propylthiouracil, benzylthiouracil

Caesarean

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3441
R6398		 Zhang, 2016 Cesarean during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 2.26 [0.69;7.45] C 20/43   5/18 25 43
ref
S3564
R7107		 Gianetti (control exposed to MMI), 2015 Non vaginal delivery at least 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 1.58 [0.69;3.63] C
excluded (control group) 		11/52   18/124 29 52
ref
S3565
R7118		 Gianetti (control unexposed, sick), 2015 Non vaginal delivery throughout pregnancy retrospective cohort unexposed, sick Adjustment: No 0.62 [0.30;1.30] C 11/52   61/203 72 52
ref
Total 2 studies 1.09 [0.31;3.78] 97 95
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Zhang, 2016Zhang, 2016 2.26[0.69; 7.45]254343%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Gianetti (control unexposed, sick), 2015Gianetti, 2015 1 0.62[0.30; 1.30]725257%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: critical Total (2 studies) I2 = 69% 1.09[0.31; 3.78]97950.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.09[0.31; 3.78]979569%NAZhang, 2016 Gianetti (control unexposed, sick), 2015 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.09[0.31; 3.78]979569%NAZhang, 2016 Gianetti (control unexposed, sick), 2015 2 Tags Adjustment   - No  - No 1.09[0.31; 3.78]979569%NAZhang, 2016 Gianetti (control unexposed, sick), 2015 2 All studiesAll studies 1.09[0.31; 3.78]979569%NAZhang, 2016 Gianetti (control unexposed, sick), 2015 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3564

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.09[0.31; 3.78]979569%NAZhang, 2016 Gianetti (control unexposed, sick), 2015 20.510.01.0