Thiouracil, propylthiouracil, benzylthiouracil

Hearing loss / Auditory deficit

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8484
R27842		 Yoshihara (Controls exposed to MMI), 2021 Congenital hearing loss 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.13 [0.00;3.16] C
excluded (control group) 		1/541   0/23 1 541
ref
S8481
R27776		 Yoshihara (Controls unexposed, sick), 2021 Congenital hearing loss 1st trimester retrospective cohort unexposed, sick Adjustment: No 0.29 [0.03;2.81] C 1/541   3/475 4 541
ref
S3355
R6091		 Yoshihara (control exposed to MMI), 2012 Hearing loss 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.29 [0.01;7.20] C
excluded (control group) 		0/1,399   1/1,231 1 1,399
ref
S3354
R6048		 Yoshihara (control unexposed, sick), 2012 Hearing loss 1st trimester retrospective cohort unexposed, sick Adjustment: No 1.36 [0.03;68.71] C 0/1,399   0/1,906 0 1,399
ref
Total 2 studies 0.43 [0.06;3.05] 4 1,940
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yoshihara (Controls unexposed, sick), 2021Yoshihara, 2021 1 0.29[0.03; 2.81]454175%ROB confusion: criticalROB selection: moderateROB classification: unclearROB missing: unclearROB mesure: criticalROB reporting: moderate Yoshihara (control unexposed, sick), 2012Yoshihara, 2012 2 1.36[0.03; 68.71]01,39925%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 0.43[0.06; 3.05]41,9400.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick; 2: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.43[0.06; 3.05]41,9400%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.43[0.06; 3.05]41,9400%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 Tags Adjustment   - No  - No 0.43[0.06; 3.05]41,9400%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 All studiesAll studies 0.43[0.06; 3.05]41,9400%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 20.15.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3355, 8484

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.43[0.06; 3.05]41,9400%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.19[0.02; 1.87]21,9400%NAYoshihara (Controls exposed to MMI), 2021 Yoshihara (control exposed to MMI), 2012 20.510.01.0