Thiouracil, propylthiouracil, benzylthiouracil

Oro-facial clefts

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8484
R27839		 Yoshihara (Controls exposed to MMI), 2021 Cheiloschisis, palatoschisis 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.13 [0.00;3.16] C
excluded (control group) 		1/541   0/23 1 541
ref
S8481
R27773		 Yoshihara (Controls unexposed, sick), 2021 Cheiloschisis, palatoschisis 1st trimester retrospective cohort unexposed, sick Adjustment: No 0.88 [0.05;14.07] C 1/541   1/475 2 541
ref
S3366
R6156		 Seo (control exposed to MMI), 2018 Cleft lip and cleft palate (Q35–Q37) 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 1.35 [0.18;10.42] C
excluded (control group) 		12/9,930   1/1,120 13 9,930
ref
S3367
R6168		 Seo (control unexposed, NOS), 2018 Cleft lip and cleft palate (Q35–Q37) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 0.98 [0.56;1.73] 12/9,930   3,446/2,872,109 3,458 9,930
ref
Total 2 studies 0.98 [0.56;1.70] 3,460 10,471
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yoshihara (Controls unexposed, sick), 2021Yoshihara, 2021 1 0.88[0.05; 14.07]25414%ROB confusion: criticalROB selection: moderateROB classification: unclearROB missing: unclearROB mesure: criticalROB reporting: moderate Seo (control unexposed, NOS), 2018Seo, 2018 2 0.98[0.56; 1.73]3,4589,93096%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.98[0.56; 1.70]3,46010,4710.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick; 2: control unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.98[0.56; 1.70]3,46010,4710%NAYoshihara (Controls unexposed, sick), 2021 Seo (control unexposed, NOS), 2018 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.98[0.56; 1.72]3,4589,930 -NASeo (control unexposed, NOS), 2018 1 unexposed, sickunexposed, sick 0.88[0.05; 14.07]2541 -NAYoshihara (Controls unexposed, sick), 2021 1 Tags Adjustment   - No  - No 0.88[0.05; 14.07]2541 -NAYoshihara (Controls unexposed, sick), 2021 1   - Yes  - Yes 0.98[0.56; 1.72]3,4589,930 -NASeo (control unexposed, NOS), 2018 1 All studiesAll studies 0.98[0.56; 1.70]3,46010,4710%NAYoshihara (Controls unexposed, sick), 2021 Seo (control unexposed, NOS), 2018 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3366, 8484

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.98[0.56; 1.72]3,4589,930 -NASeo (control unexposed, NOS), 2018 1 unexposed, sick controlsunexposed, sick controls 0.88[0.05; 14.07]2541 -NAYoshihara (Controls unexposed, sick), 2021 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.58[0.06; 5.42]1410,47133%NAYoshihara (Controls exposed to MMI), 2021 Seo (control exposed to MMI), 2018 20.510.01.0