Thiouracil, propylthiouracil, benzylthiouracil

Early intrauterine death (< 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3355
R6057		 Yoshihara (control exposed to MMI), 2012 Miscarriage 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.90 [0.71;1.13] C
excluded (control group) 		166/1,578   165/1,426 331 1,578
ref
S3354
R6014		 Yoshihara (control unexposed, sick), 2012 Miscarriage 1st trimester retrospective cohort unexposed, sick Adjustment: No 1.55 [1.22;1.95] C 166/1,578   146/2,065 312 1,578
ref
S3374
R6200		 Rosenfeld, 2009 Miscarriages during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No 1.26 [0.61;2.59] C 9/115   72/1,141 81 115
ref
S3439
R6389		 Davis, 1989 Abortions during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 0.04 [0.00;1.14] C 0/52   1/8 1 52
ref
Total 3 studies 1.24 [0.62;2.47] 394 1,745
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yoshihara (control unexposed, sick), 2012Yoshihara, 2012 1 1.55[1.22; 1.95]3121,57859%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Rosenfeld, 2009Rosenfeld, 2009 1.26[0.61; 2.59]8111537%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: criticalROB reporting: moderate Davis, 1989Davis, 1989 0.04[0.00; 1.14]1524%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: unclear Total (3 studies) I2 = 58% 1.24[0.62; 2.47]3941,7450.05.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.24[0.62; 2.47]3941,74558%NAYoshihara (control unexposed, sick), 2012 Rosenfeld, 2009 Davis, 1989 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.26[0.61; 2.59]81115 -NARosenfeld, 2009 1 unexposed, sickunexposed, sick 0.38[0.01; 11.85]3131,63078%NAYoshihara (control unexposed, sick), 2012 Davis, 1989 2 Tags Adjustment   - No  - No 1.24[0.62; 2.47]3941,74558%NAYoshihara (control unexposed, sick), 2012 Rosenfeld, 2009 Davis, 1989 3 All studiesAll studies 1.24[0.62; 2.47]3941,74558%NAYoshihara (control unexposed, sick), 2012 Rosenfeld, 2009 Davis, 1989 30.05.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3355

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.26[0.61; 2.59]81115 -NARosenfeld, 2009 1 unexposed, sick controlsunexposed, sick controls Out of scale0.38[0.01; 11.85]3131,63078%NAYoshihara (control unexposed, sick), 2012 Davis, 1989 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.90[0.71; 1.13]3311,578 -NAYoshihara (control exposed to MMI), 2012 10.510.01.0