Tenofovir (all routes except local)

Eye, ear, face and neck malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5128
R13334		 Sibiude, 2014 Head and Neck (including eyes and ears) 1st trimester prospective cohort exposed to other treatment, sick Adjustment: No Control group: non-TDF (mix or unspecified regimens) Exposed group: TDF (mix or unspecified regimens) Indication: HIV 1.27 [0.30;5.41] -/823   -/12,043 - 823
ref
S5132
R13370		 Floridia, 2013 Face and neck malformations 1st trimester prospective cohort unexposed, sick Adjustment: No Control group: Unexposed, sick Exposed group: TDF (mix or unspecified regimens) Indication: HIV 3.25 [0.06;164.37] C 0/173   0/561 0 173
ref
Total 2 studies 1.42 [0.37;5.52] 0 996
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Sibiude, 2014Sibiude, 2014 1.27[0.30; 5.41]-82388%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Floridia, 2013Floridia, 2013 3.25[0.06; 164.37]017312%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.42[0.37; 5.52]-9960.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.42[0.37; 5.52]-9960%NASibiude, 2014 Floridia, 2013 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 3.25[0.06; 164.37]-173 -NAFloridia, 2013 1 exposed to other treatment, sickexposed to other treatment, sick 1.27[0.30; 5.39]-823 -NASibiude, 2014 1 Tags Adjustment   - No  - No 1.42[0.37; 5.52]-9960%NASibiude, 2014 Floridia, 2013 2 Control group   - non-TDF (mix or unspecified regimens)  - non-TDF (mix or unspecified regimens) 1.27[0.30; 5.39]-823 -NASibiude, 2014 1   - Unexposed, sick  - Unexposed, sick 3.25[0.06; 164.37]-173 -NAFloridia, 2013 1 Exposed group   - TDF (mix or unspecified regimens)  - TDF (mix or unspecified regimens) 1.42[0.37; 5.52]-9960%NASibiude, 2014 Floridia, 2013 2 Indication   - HIV  - HIV 1.42[0.37; 5.52]-9960%NASibiude, 2014 Floridia, 2013 2 All studiesAll studies 1.42[0.37; 5.52]-9960%NASibiude, 2014 Floridia, 2013 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 3.25[0.06; 164.37]-173 -NAFloridia, 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.27[0.30; 5.39]-823 -NASibiude, 2014 10.510.01.0