Tacrolimus (all routes)

Small for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12404
R46263		 Perales-Puchalt, 2012 Small for gestational age (SGA) (birth weight bellow 10th percentile with normal Doppler) throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No Co-exposure Mycophenolate: no 3.40 [0.12;96.71] C 1/9   0/9 1 9
ref
S5783
R14450		 Thompson, 2003 Fetal growth restriction / small for gestational age throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No Co-exposure Mycophenolate: no 0.43 [0.04;4.82] C 1/4   10/23 11 4
ref
Total 2 studies 0.87 [0.12;6.18] 12 13
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Perales-Puchalt, 2012Perales-Puchalt, 2012 3.40[0.12; 96.71]1934%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Thompson, 2003Thompson, 2003 0.43[0.04; 4.82]11466%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.87[0.12; 6.18]12130.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.87[0.12; 6.18]12130%NAPerales-Puchalt, 2012 Thompson, 2003 2 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 0.87[0.12; 6.18]12130%NAPerales-Puchalt, 2012 Thompson, 2003 2 Tags Adjustment   - No  - No 0.87[0.12; 6.18]12130%NAPerales-Puchalt, 2012 Thompson, 2003 2 Co-exposure Mycophenolate   - no  - no 0.87[0.12; 6.18]12130%NAPerales-Puchalt, 2012 Thompson, 2003 2 All studiesAll studies 0.87[0.12; 6.18]12130%NAPerales-Puchalt, 2012 Thompson, 2003 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.87[0.12; 6.18]12130%NAPerales-Puchalt, 2012 Thompson, 2003 20.510.01.0