Triptans

Early intrauterine death (< 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3510
R6879		 Spielmann (Control mainly exposed other treatments, sick), 2017 Spontaneous abortion (<23 weeks of gestation or <500 g) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: Yes 1.41 [0.90;2.20]
excluded (control group) 		50/432   37/475 87 432
ref
S3509
R6855		 Spielmann (Control unexposed, disease free), 2017 Spontaneous abortion (<23 weeks of gestation or <500 g) during pregnancy (anytime or not specified) prospective cohort unexposed, disease free Adjustment: Yes 1.20 [0.90;1.70] 50/432   159/1,733 209 432
ref
S3593
R7289		 O'Quinn - Sumatriptan, 1999 Spontaneous abortion (NOS) 1st trimester prospective cohort unexposed, sick Adjustment: No 0.87 [0.33;2.28] C 8/76   11/92 19 76
ref
S3595
R7302		 Shuhaiber - Sumatriptan (Control exposed to other treatments), 1998 Spontaneous abortions, miscarriages (NOS) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No 1.94 [0.69;5.48] C
excluded (control group) 		11/96   6/96 17 96
ref
S3596
R7306		 Shuhaiber - Sumatriptan (Control unexposed, disease free), 1998 Spontaneous abortions, miscarriages (NOS) during pregnancy (anytime or not specified) prospective cohort unexposed, disease free Adjustment: No 2.98 [0.91;9.70] C 11/96   4/96 15 96
ref
Total 3 studies 1.27 [0.80;2.02] 243 604
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Spielmann (Control unexposed, disease free), 2017Spielmann, 2017 1 1.20[0.90; 1.70]20943268%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA O'Quinn - Sumatriptan, 1999O'Quinn - Sumatriptan, 1999 0.87[0.33; 2.28]197619%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Shuhaiber - Sumatriptan (Control unexposed, disease free), 1998Shuhaiber - Sumatriptan, 1998 2 2.98[0.91; 9.70]159613%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 25% 1.27[0.80; 2.02]2436040.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed, disease free; 2: Control unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.27[0.80; 2.02]24360425%NASpielmann (Control unexposed, disease free), 2017 O'Quinn - Sumatriptan, 1999 Shuhaiber - Sumatriptan (Control unexposed, disease free), 1998 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.57[0.70; 3.54]22452853%NASpielmann (Control unexposed, disease free), 2017 Shuhaiber - Sumatriptan (Control unexposed, disease free), 1998 2 unexposed, sickunexposed, sick 0.87[0.33; 2.28]1976 -NAO'Quinn - Sumatriptan, 1999 1 Tags Adjustment   - No  - No 1.53[0.46; 5.11]3417260%NAO'Quinn - Sumatriptan, 1999 Shuhaiber - Sumatriptan (Control unexposed, disease free), 1998 2   - Yes  - Yes 1.20[0.87; 1.65]209432 -NASpielmann (Control unexposed, disease free), 2017 1 All studiesAll studies 1.27[0.80; 2.02]24360425%NASpielmann (Control unexposed, disease free), 2017 O'Quinn - Sumatriptan, 1999 Shuhaiber - Sumatriptan (Control unexposed, disease free), 1998 30.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3595, 3510

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.91[0.99; 3.69]4,99361074%NASpielmann (Control unexposed, disease free), 2017 Bérard, 2012 Shuhaiber - Sumatriptan (Control unexposed, disease free), 1998 3 unexposed, sick controlsunexposed, sick controls 0.87[0.33; 2.28]1976 -NAO'Quinn - Sumatriptan, 1999 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.48[0.98; 2.23]1045280%NASpielmann (Control mainly exposed other treatments, sick), 2017 Shuhaiber - Sumatriptan (Control exposed to other treatments), 1998 20.510.01.0