Triptans

Small for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3535
R6992
Wood 2016a (Control exposed only before pregnancy), 2016 Small for Gestational Age during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 1.05 [0.64;1.72] C 26/396   50/798 76 396
ref
S3539
R7008
Wood 2016a (Control mainly exposed to other treatments, sick), 2016 Small for Gestational Age during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: Yes 1.06 [0.70;1.62] C
excluded (control group)
26/396   204/3,291 230 396
ref
S3538
R6999
Wood 2016a (Control unexposed, disease free), 2016 Small for Gestational Age during pregnancy (anytime or not specified) prospective cohort unexposed, disease free excluded Adjustment: No 1.06 [0.71;1.59] C
excluded (control group)
26/396   2,275/36,688 2,301 396
ref
S3492
R6771
Nezvalová-Henriksen (Control unexposed, disease free), 2013 Small for gestational age (birthweight < 10th percentile for gestational age) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 1.08 [0.90;1.30]
excluded (control group)
132/1,465   14,395/178,565 14,527 1,465
ref
S851
R6754
Nezvalová-Henriksen (Control unexposed, sick), 2013 Small for gestational age (birthweight < 10th percentile for gestational age) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: No 1.09 [0.83;1.44] C 132/1,465   91/1,095 223 1,465
ref
Total 2 studies 1.08 [0.85;1.38] 299 1,861
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Wood 2016a (Control exposed only before pregnancy), 2016Wood 2016a, 2016 1 1.05[0.64; 1.72]7639625%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Nezvalová-Henriksen (Control unexposed, sick), 2013Nezvalová-Henriksen, 2013 2 1.09[0.83; 1.44]2231,46575%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.08[0.85; 1.38]2991,8610.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control exposed only before pregnancy; 2: Control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.08[0.85; 1.38]2991,8610%NAWood 2016a (Control exposed only before pregnancy), 2016 Nezvalová-Henriksen (Control unexposed, sick), 2013 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.08[0.85; 1.38]2991,8610%NAWood 2016a (Control exposed only before pregnancy), 2016 Nezvalová-Henriksen (Control unexposed, sick), 2013 2 Tags Adjustment   - No  - No 1.08[0.85; 1.38]2991,8610%NAWood 2016a (Control exposed only before pregnancy), 2016 Nezvalová-Henriksen (Control unexposed, sick), 2013 2 All studiesAll studies 1.08[0.85; 1.38]2991,8610%NAWood 2016a (Control exposed only before pregnancy), 2016 Nezvalová-Henriksen (Control unexposed, sick), 2013 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3492, 3539, 3538

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.08[0.91; 1.27]16,8281,8610%NAWood 2016a (Control unexposed, disease free), 2016 Nezvalová-Henriksen (Control unexposed, disease free), 2013 2 unexposed, sick controlsunexposed, sick controls 1.08[0.85; 1.38]2991,8610%NAWood 2016a (Control exposed only before pregnancy), 2016 Nezvalová-Henriksen (Control unexposed, sick), 2013 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.06[0.70; 1.62]230396 -NAWood 2016a (Control mainly exposed to other treatments, sick), 2016 10.510.01.0