Carbimazole, Thiamazole (Methimazole)

Carbimazole embryopathy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3379
R8736		 Clementi, 2010 Choanal atresia or omphalocele (as a part of Carbimazole embryopathy) 1st trimester case control unexposed (general population or NOS) Adjustment: No 11.85 [6.16;22.81] C 10/160   202/36,102 212 160
ref
S3357
R8724		 Barbero, 2008 Choanal atresia (as a part of Carbimazole embryopathy) 1st trimester case control unexposed, disease free Adjustment: No 17.75 [3.49;121.40] 10/12   51/232 61 12
ref
Total 2 studies 12.44 [6.73;22.99] 273 172
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Clementi, 2010Clementi, 2010 11.85[6.16; 22.81]21216088%ROB confusion: criticalROB selection: criticalROB classification: unclearROB missing: unclearROB mesure: criticalROB reporting: critical Barbero, 2008Barbero, 2008 17.75[3.49; 121.40]611212%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: criticalROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 12.44[6.73; 22.99]2731720.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 12.44[6.73; 22.99]2731720%NAClementi, 2010 Barbero, 2008 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 12.44[6.73; 22.99]2731720%NAClementi, 2010 Barbero, 2008 2 Tags Adjustment   - No  - No 12.44[6.73; 22.99]2731720%NAClementi, 2010 Barbero, 2008 2 All studiesAll studies 12.44[6.73; 22.99]2731720%NAClementi, 2010 Barbero, 2008 20.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale14.37[10.20; 20.26]2,3023,0700%NAAndersen (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Clementi, 2010 Barbero, 2008 Di Gianantonio, 2001 5 unexposed, sick controlsunexposed, sick controls Out of scale45.42[2.71; 762.21]141,231 -NAYoshihara (control unexposed, sick), 2012 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 8.21[2.20; 30.64]342,35123%NASeo (control exposed to PTU), 2018 Yoshihara (control exposed to PTU), 2012 20.510.01.0