Carbimazole, Thiamazole (Methimazole)

Omphalocele

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3379
R6253
Clementi, 2010 Omphalocele 1st trimester case control unexposed (general population or NOS) Adjustment: Yes 10.40 [2.90;37.26] 6/80   148/18,051 154 80
ref
Total 1 studies 10.40 [2.90;37.28] 154 80
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Clementi, 2010Clementi, 2010 10.40[2.90; 37.26]154800%ROB confusion: criticalROB selection: criticalROB classification: unclearROB missing: unclearROB mesure: criticalROB reporting: critical0.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 10.40[2.90; 37.28]15480 -NAClementi, 2010 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 10.40[2.90; 37.28]15480 -NAClementi, 2010 1 Tags Adjustment   - Yes  - Yes 10.40[2.90; 37.28]15480 -NAClementi, 2010 1 All studiesAll studies 10.40[2.90; 37.28]15480 -NAClementi, 2010 10.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale10.40[2.90; 37.28]15480 -NAClementi, 2010 1 unexposed, sick controlsunexposed, sick controls 8.08[1.02; 64.32]91,2540%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 8.74[1.07; 71.21]81,2540%NAYoshihara (Controls exposed to PTU), 2021 Yoshihara (control exposed to PTU), 2012 20.510.01.0