Carbimazole, Thiamazole (Methimazole)

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3414
R35109		 Banhidy, 2011 Congenital abnormalities at least 1st trimester case control unexposed, sick Adjustment: No 0.81 [0.14;4.55] C 2/6   69/181 71 6
ref
S3362
R11295		 Khoury, 1989 Major birth defects during pregnancy (anytime or not specified) excluded case control unexposed (general population or NOS) Adjustment: No 0.41 [0.07;2.46] C
excluded (exposition period) 		2/5   4,902/7,926 4,904 5
ref
Total 1 studies 0.81 [0.14;4.55] 71 6
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Banhidy, 2011Banhidy, 2011 0.81[0.14; 4.55]7160%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.81[0.14; 4.55]716 -NABanhidy, 2011 1 Type of controls unexposed, sickunexposed, sick 0.81[0.14; 4.55]716 -NABanhidy, 2011 1 Tags Adjustment   - No  - No 0.81[0.14; 4.55]716 -NABanhidy, 2011 1 All studiesAll studies 0.81[0.14; 4.55]716 -NABanhidy, 2011 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.34[1.16; 1.55]303,6183,0839%NAAndersen (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, disease free), 2017 Azizi, 2002 Di Gianantonio, 2001 5 unexposed, sick controlsunexposed, sick controls 1.02[0.51; 2.05]3471,82554%NAYoshihara (Controls unexposed, sick), 2021 Andersen 2017 (control unexposed, sick), 2017 Gianetti (control unexposed, sick), 2015 Yoshihara (control unexposed, sick), 2012 Banhidy, 2011 Wing (control unexposed, sick), 1994 Momotani, 1984 7 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.30[0.95; 1.78]1,1544,29741%NAYoshihara (Controls exposed to PTU), 2021 Andersen (control exposed to PTU), 2019 Seo (control exposed to PTU), 2018 Andersen 2017 (control exposed to PTU), 2017 Hawken (control exposed to PTU), 2016 Gianetti (control exposed to PTU), 2015 Yoshihara (control exposed to PTU), 2012 Dwarakanath (control exposed to PTU), 1999 Wing (control exposed to PTU), 1994 90.510.01.0

Umbrella review (other published meta-analyses)

Published MATE95% CIn exposedkI2Control groupExposition period SongSong 1.72[1.41; 2.09]40%-unexposed, sickduring pregnancy (anytime or not specified)studies8 SongSong 1.61[1.32; 1.97]1%-unexposed, disease freeduring pregnancy (anytime or not specified)studies4 SongSong 1.88[1.33; 2.65]41%-unexposed, sickduring pregnancy (anytime or not specified)studies6 Li 2015aLi 2015a 1.71[1.39; 2.10]0%-unexposed, sickduring pregnancy (anytime or not specified)studies5 Li 2015aLi 2015a 1.37[1.04; 1.79]42%-exposed to other treatment, sickduring pregnancy (anytime or not specified)studies5 Li 2015bLi 2015b 1.64[1.39; 1.92]35%-whatever (meta-analysis)during pregnancy (anytime or not specified)studies7 MoralesMorales 1.64[1.39; 1.92]35%-unexposed (general population or NOS)during pregnancy (anytime or not specified)studies7 MoralesMorales 1.28[1.06; 1.54]33%-unexposed (general population or NOS)during pregnancy (anytime or not specified)studies4 MoralesMorales 1.29[1.05; 1.59]-unexposed (general population or NOS)1st trimesterstudies3 metaPregmetaPreg 0.81[0.14; 4.55]NaN%6--Banhidy, 2011 10.510.01.0