Carbimazole, Thiamazole (Methimazole)

Major congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3414
R6366
Banhidy, 2011 Congenital abnormalities at least 1st trimester case control unexposed, sick Adjustment: No 0.81 [0.14;4.55] C 2/6   69/181 71 6
ref
S3362
R6113
Khoury, 1989 Major birth defects during pregnancy (anytime or not specified) excluded case control unexposed (general population or NOS) Adjustment: No 0.41 [0.07;2.46] C
excluded (exposition period)
2/5   4,902/7,926 4,904 5
ref
Total 1 studies 0.81 [0.14;4.55] 71 6
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Banhidy, 2011Banhidy, 2011 0.81[0.14; 4.55]7160%ROB confusion: seriousROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.81[0.14; 4.55]716 -NABanhidy, 2011 1 Type of controls unexposed, sickunexposed, sick 0.81[0.14; 4.55]716 -NABanhidy, 2011 1 Tags Adjustment   - No  - No 0.81[0.14; 4.55]716 -NABanhidy, 2011 1 All studiesAll studies 0.81[0.14; 4.55]716 -NABanhidy, 2011 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.89[0.83; 4.29]31204 -NADi Gianantonio, 2001 1 unexposed, sick controlsunexposed, sick controls 1.41[0.68; 2.92]1731,64024%NAGianetti (control unexposed, sick), 2015 Yoshihara (control unexposed, sick), 2012 Banhidy, 2011 Wing (control unexposed, sick), 1994 Momotani, 1984 5 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.06[0.19; 5.99]801,39954%NAGianetti (control exposed to PTU), 2015 Yoshihara (control exposed to PTU), 2012 Dwarakanath (control exposed to PTU), 1999 Wing (control exposed to PTU), 1994 40.510.01.0

Umbrella review (other published meta-analyses)

Published MATE95% CIn exposedkI2Control groupExposition period SongSong 1.75[1.22; 2.53]0%-unexposed, sickduring pregnancy (anytime or not specified)studies4 SongSong 2.75[0.58; 12.96]0%-unexposed, disease freeduring pregnancy (anytime or not specified)studies2 SongSong 1.73[1.15; 2.59]11%-exposed to other treatment, sickduring pregnancy (anytime or not specified)studies4 Li 2015bLi 2015b 1.64[1.39; 1.94]0%-whatever (meta-analysis)during pregnancy (anytime or not specified)studies5 metaPregmetaPreg 0.81[0.14; 4.55]NaN%6--Banhidy, 2011 10.510.01.0