Thiouracil, propylthiouracil, benzylthiouracil

Aortic valve atresia/stenosis

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3359
R6110
Howley, 2017 Aortic valve stenosis 1st trimester case control unexposed, disease free Adjustment: No 13.80 [2.13;71.20] 3/13   490/11,780 493 13
ref
Total 1 studies 13.80 [2.39;79.79] 493 13
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Howley, 2017Howley, 2017 13.80[2.13; 71.20]493130%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate0.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 13.80[2.39; 79.79]49313 -NAHowley, 2017 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 13.80[2.39; 79.79]49313 -NAHowley, 2017 1 Tags Adjustment   - No  - No 13.80[2.39; 79.79]49313 -NAHowley, 2017 1 All studiesAll studies 13.80[2.39; 79.79]49313 -NAHowley, 2017 10.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale13.80[2.39; 79.79]49313 -NAHowley, 2017 1 unexposed, sick controlsunexposed, sick controls Out of scale0.45[0.02; 11.15]11,399 -NAYoshihara (control unexposed, sick), 2012 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.88[0.02; 44.38]-1,399 -NAYoshihara (control exposed to MMI), 2012 10.510.01.0