Thiouracil, propylthiouracil, benzylthiouracil

Severe congenital heart defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3380
R6260		 Clementi, 2010 Cardiac outflow tract defects (OTD) 1st trimester case control unexposed (general population or NOS) Adjustment: Yes 4.12 [1.06;16.06] 5/47   731/18,084 736 47
ref
Total 1 studies 4.12 [1.06;16.04] 736 47
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Clementi, 2010Clementi, 2010 4.12[1.06; 16.06]736470%ROB confusion: criticalROB selection: criticalROB classification: unclearROB missing: unclearROB mesure: criticalROB reporting: critical0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 4.12[1.06; 16.04]73647 -NAClementi, 2010 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 4.12[1.06; 16.04]73647 -NAClementi, 2010 1 Tags Adjustment   - Yes  - Yes 4.12[1.06; 16.04]73647 -NAClementi, 2010 1 All studiesAll studies 4.12[1.06; 16.04]73647 -NAClementi, 2010 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 4.12[1.06; 16.04]73647 -NAClementi, 2010 1 unexposed, sick controlsunexposed, sick controls Out of scale0.19[0.01; 3.77]31,399 -NAYoshihara (control unexposed, sick), 2012 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.88[0.02; 44.38]-1,399 -NAYoshihara (control exposed to MMI), 2012 10.510.01.0