Thiouracil, propylthiouracil, benzylthiouracil

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3415
R35108		 Banhidy, 2011 Congenital abnormalities throughout pregnancy case control unexposed, sick Adjustment: No 1.64 [0.10;26.69] C 1/2   70/185 71 2
ref
Total 1 studies 1.64 [0.10;26.69] 71 2
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Banhidy, 2011Banhidy, 2011 1.64[0.10; 26.69]7120%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.64[0.10; 26.69]712 -NABanhidy, 2011 1 Type of controls unexposed, sickunexposed, sick 1.64[0.10; 26.69]712 -NABanhidy, 2011 1 Tags Adjustment   - No  - No 1.64[0.10; 26.69]712 -NABanhidy, 2011 1 All studiesAll studies 1.64[0.10; 26.69]712 -NABanhidy, 2011 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.15[1.07; 1.24]304,15611,1170%NAAndersen 2019 (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, disease free), 2017 Rosenfeld, 2009 4 unexposed, sick controlsunexposed, sick controls 0.78[0.58; 1.04]3512,3110%NAYoshihara (Controls unexposed, sick), 2021 Andersen 2017 (control unexposed, sick), 2017 Gianetti (control unexposed, sick), 2015 Yoshihara (control unexposed, sick), 2012 Banhidy, 2011 Wing (control unexposed, sick), 1994 6 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.76[0.55; 1.04]1,15313,14147%NAYoshihara (Controls exposed to MMI), 2021 Andersen 2019 (control exposed to MMI/CMZ), 2019 Seo (control exposed to MMI), 2018 Andersen 2017 (control exposed to MMI/CMZ), 2017 Hawken (control exposed to MMI), 2016 Gianetti (control exposed to MMI), 2015 Yoshihara (control exposed to MMI), 2012 Wing (control exposed to MMI), 1994 80.510.01.0