Triptans

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S850
R6552
Bérard, 2012 Prematurity (<37 weeks of gestation) during pregnancy (anytime or not specified) nested case control unexposed, disease free Adjustment: Yes 0.76 [0.34;1.66] 7/139   3,934/59,568 3,941 139
ref
Total 1 studies 0.76 [0.34;1.68] 3,941 139
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bérard, 2012Bérard, 2012 0.76[0.34; 1.66]3,9411390%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.76[0.34; 1.68]3,941139 -NABérard, 2012 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.76[0.34; 1.68]3,941139 -NABérard, 2012 1 Tags Adjustment   - Yes  - Yes 0.76[0.34; 1.68]3,941139 -NABérard, 2012 1 All studiesAll studies 0.76[0.34; 1.68]3,941139 -NABérard, 2012 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.08[0.81; 1.45]19,9732,48067%NASpielmann (Control unexposed, disease free), 2017 Wood 2016a (Control unexposed, disease free), 2016 Nezvalová-Henriksen (Control unexposed, disease free), 2013 Bérard, 2012 Källén (control unexposed, disease free), 2011 Olesen - Sumatriptan (Control unexposed, disease free), 2000 Shuhaiber - Sumatriptan (Control unexposed, disease free), 1998 7 unexposed, sick controlsunexposed, sick controls 1.00[0.46; 2.17]2611,89576%NAWood 2016a (Control exposed only before pregnancy), 2016 Nezvalová-Henriksen (Control unexposed, sick), 2013 Olesen - Sumatriptan (Control unexposed, sick), 2000 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.88[0.55; 1.40]27884233%NASpielmann (Control mainly exposed other treatments, sick), 2017 Wood 2016a (Control mainly exposed to other treatments, sick), 2016 Shuhaiber - Sumatriptan (Control exposed to other treatments), 1998 30.510.01.0