Triptans

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S850
R6717		 Bérard, 2012 Low birth weight (LBW) (<2500 g) during pregnancy (anytime or not specified) nested case control unexposed, disease free Adjustment: Yes 0.83 [0.31;2.25] 6/139   3,383/59,568 3,389 139
ref
Total 1 studies 0.83 [0.31;2.24] 3,389 139
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bérard, 2012Bérard, 2012 0.83[0.31; 2.25]3,3891390%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.83[0.31; 2.24]3,389139 -NABérard, 2012 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.83[0.31; 2.24]3,389139 -NABérard, 2012 1 Tags Adjustment   - Yes  - Yes 0.83[0.31; 2.24]3,389139 -NABérard, 2012 1 All studiesAll studies 0.83[0.31; 2.24]3,389139 -NABérard, 2012 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.13[0.93; 1.38]11,8292,6920%NAWood 2016a (Control unexposed, disease free), 2016 Nezvalová-Henriksen (Control unexposed, disease free), 2013 Bérard, 2012 Kallen - Sumatriptan, 2001 Olesen - Sumatriptan (Control unexposed, disease free), 2000 5 unexposed, sick controlsunexposed, sick controls 0.85[0.62; 1.16]1731,8950%NAWood 2016a (Control exposed only before pregnancy), 2016 Nezvalová-Henriksen (Control unexposed, sick), 2013 Olesen - Sumatriptan (Control unexposed, sick), 2000 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.77[0.37; 1.60]94396 -NAWood 2016a (Control mainly exposed to other treatments, sick), 2016 10.510.01.0