Ondansetron

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Congenital malformations
Adverse outcome PastilleOR 95%CII2k No. casesNo. exposedpublication biasROB???
All congenital malformations (majors, minors, majors and minors, or unspecified)no evidence of harm1.04 [0.96, 1.12]43%8 studies167,592116,161not evaluable unclearpptx
Cleft lip with or without cleft palateno evidence of harm1.03 [0.88, 1.21]0%7 studies4,58592,238not evaluable unclearpptx
Congenital heart defectsinsufficient precision1.13 [0.96, 1.33]66%6 studies59,616116,155not evaluable unclearpptx
Major congenital malformationsno evidence of harm1.02 [0.99, 1.05]0%7 studies150,947115,320not evaluable unclearpptx
Ventricular septal defectinsufficient precision1.13 [0.99, 1.27]25%7 studies19,11096,086not evaluable unclearpptx
Cleft palateinsufficient precision1.26 [0.87, 1.82]65%6 studies3,36391,261not evaluable unclearpptx
Atrial septal defectinsufficient precision1.05 [0.79, 1.39]84%5 studies5,71591,265not evaluable unclearpptx
Hypospadiasno evidence of harm0.90 [0.70, 1.15]0%5 studies3,3231,874not evaluable unclearpptx
Oro-facial cleftsharm, strong evidence1.20 [1.02, 1.40]0%4 studies3,506113,549not evaluable unclearpptx
Atrioventricular septal defectinsufficient precision1.38 [0.65, 2.93]73%4 studies6,19090,765not evaluable unclearpptx
Club foot / Talipes equinovarusinsufficient precision1.09 [0.83, 1.44]0%4 studies1,0612,714not evaluable unclearpptx
Limb defectsno evidence of harm1.02 [0.92, 1.11]0%4 studies8,42590,330not evaluable unclearpptx
Ano-rectal atresia and stenosisinsufficient precision0.79 [0.49, 1.27]0%3 studies6711,881not evaluable unclearpptx
Atresia or stenosis of other parts of small intestineinsufficient precision0.97 [0.61, 1.53]0%3 studies3941,880not evaluable unclearpptx
Coarctation of aortainsufficient precision0.95 [0.69, 1.29]0%3 studies8441,903not evaluable unclearpptx
Craniosynostosisinsufficient precision1.13 [0.95, 1.35]0%3 studies12,7652,512not evaluable unclearpptx
Diaphragmatic herniaharm, strong evidence1.70 [1.17, 2.48]0%3 studies8752,394not evaluable unclearpptx
Gastroschisisinsufficient precision0.89 [0.61, 1.29]0%3 studies9591,894not evaluable unclearpptx
Hypoplastic left heartharm, strong evidence1.49 [1.03, 2.17]0%3 studies8381,539not evaluable unclearpptx
Pulmonary valve stenosisinsufficient precision1.08 [0.79, 1.48]0%3 studies1,0251,913not evaluable unclearpptx
Severe congenital heart defectno evidence of harm0.76 [0.63, 0.93]0%2 studies1,88088,851not evaluable unclearpptx
Single ventricleinsufficient precision0.90 [0.34, 2.37]71%2 studies42488,706not evaluable unclearpptx
Total anomalous pulm venous returninsufficient precision0.84 [0.55, 1.30]0%2 studies50288,705not evaluable unclearpptx
Abdominal wall defectsno evidence of harm0.98 [0.90, 1.07]0%2 studies8,81689,679not evaluable unclearpptx
Bilateral renal agenesis including Potter syndromeharm, strong evidence1.85 [1.13, 3.02]0%2 studies1611,630not evaluable unclearpptx
Cardiac septal defectsharm, strong evidence1.57 [1.17, 2.12]43%2 studies39,4752,528not evaluable unclearpptx
Congenital cataractinsufficient precision0.94 [0.46, 1.91]0%2 studies2111,494not evaluable unclearpptx
Digestive system anomaliesno evidence of harm0.93 [0.85, 1.02]0%2 studies9,59889,700not evaluable unclearpptx
Eye defectsinsufficient precision0.95 [0.69, 1.30]0%2 studies77289,700not evaluable unclearpptx
Genital anomaliesno evidence of harm1.06 [0.97, 1.17]0%2 studies7,10089,679not evaluable unclearpptx
Limb reduction defectsinsufficient precision1.01 [0.39, 2.58]0%2 studies5632,115not evaluable unclearpptx
Nervous system anomaliesno evidence of harm0.94 [0.81, 1.09]0%2 studies3,49689,679not evaluable unclearpptx
Oesophageal atresia with or without tracheo-oesophageal fistulainsufficient precision0.71 [0.40, 1.28]0%2 studies3641,496not evaluable unclearpptx
Patent ductus arteriousno evidence of harm0.90 [0.73, 1.11]-1 study1,67588,446not evaluable unclearpptx
Respiratory system anomaliesharm, strong evidence1.13 [1.01, 1.27]0%2 studies3,95189,679not evaluable unclearpptx
Spina bifidainsufficient precision1.24 [0.83, 1.83]0%2 studies461620not evaluable unclearpptx
Transposition of the great vesselsno evidence of harm0.80 [0.52, 1.23]0%2 studies584649not evaluable unclearpptx
Urinary malformationsinsufficient precision1.24 [0.76, 2.01]0%2 studies17689,679not evaluable unclearpptx
Anophthalmos/micropthalmosno data0.90 [0.31, 2.65]-1 study132257not evaluable unclearpptx
Anotiano data1.10 [0.59, 2.06]-1 study354263not evaluable unclearpptx
Aortic valve atresia/stenosisno evidence of harm0.50 [0.20, 1.22]-1 study272260not evaluable unclearpptx
Atresia of bile ductsno data1.30 [0.51, 3.29]-1 study101258not evaluable unclearpptx
Choanal atresiainsufficient precision1.33 [0.05, 32.76]-1 study11,233not evaluable unclearpptx
Congenital constriction bands/amniotic bandno data1.30 [0.51, 3.29]-1 study155258not evaluable unclearpptx
Congenital glaucomainsufficient precision4.00 [0.25, 64.04]-1 study21,233not evaluable unclearpptx
Congenital hydronephrosisinsufficient precision0.80 [0.17, 3.65]-1 study121,233not evaluable unclearpptx
Congenital skin disordersinsufficient precision0.57 [0.03, 11.07]-1 study31,233not evaluable unclearpptx
Ear malformationssignal1.67 [1.17, 2.38]-1 study45088,446not evaluable unclearpptx
Ear, face and neck anomaliesinsufficient precision4.00 [0.25, 64.04]-1 study21,233not evaluable unclearpptx
Ebstein's anomalyno data1.10 [0.39, 3.11]-1 study108257not evaluable unclearpptx
Hirschsprung's diseaseinsufficient precision1.20 [0.60, 2.40]-1 study110385not evaluable unclearpptx
Hydrocephalusno data1.40 [0.76, 2.57]-1 study254264not evaluable unclearpptx
Intestinal malrotationinsufficient precision1.10 [0.57, 2.11]-1 study125385not evaluable unclearpptx
Multicystic renal dysplasiainsufficient precision1.40 [0.83, 2.37]-1 study176394not evaluable unclearpptx
Neural Tube Defectsno data0.60 [0.21, 1.70]-1 study71148not evaluable unclearpptx
Omphaloceleno data1.10 [0.47, 2.56]-1 study187269not evaluable unclearpptx
Polydactylyinsufficient precision0.36 [0.02, 6.58]-1 study51,233not evaluable unclearpptx
Pulmonary artery atresiainsufficient precision1.33 [0.05, 32.76]-1 study11,233not evaluable unclearpptx
Pulmonary artery stenosisinsufficient precision1.33 [0.05, 32.76]-1 study11,233not evaluable unclearpptx
Pulmonary valve atresiano data0.70 [0.23, 2.10]-1 study144257not evaluable unclearpptx
Situs inversusno data0.70 [0.27, 1.81]-1 study185257not evaluable unclearpptx
Syndactylyinsufficient precision2.67 [0.45, 15.99]-1 study51,233not evaluable unclearpptx
Tetralogy of Fallotno data0.90 [0.57, 1.42]-1 study616274not evaluable unclearpptx

Growth parameters and prematurity
Adverse outcome PastilleOR 95%CII2k No. casesNo. exposedpublication biasROB???
Preterm (< 37 weeks)insufficient precision1.28 [0.76, 2.15]79%4 studies8,5763,213not evaluable unclearpptx
Low birth weight (< 2500g)insufficient precision1.04 [0.61, 1.77]50%3 studies7,4512,147not evaluable unclearpptx
Small for gestational age (weight)insufficient precision0.96 [0.69, 1.35]67%2 studies50,6642,047not evaluable unclearpptx

Maternal consequences
Adverse outcome PastilleOR 95%CII2k No. casesNo. exposedpublication biasROB???
Caesareanharm, strong evidence1.63 [1.28, 2.07]0%2 studies31,113339not evaluable unclearpptx
Preeclampsiano data4.33 [0.21, 91.53]-1 study2100not evaluable NApptx
Postpartum hemorrhageno data1.20 [0.71, 2.03]-1 study8,862251not evaluable unclearpptx

Neonatal disorders
Adverse outcome PastilleOR 95%CII2k No. casesNo. exposedpublication biasROB???
Low Apgar score (< 7) (at 5 min)no data1.89 [0.62, 5.75]0%2 studies56735not evaluable unclearpptx
Neonatal medical careinsufficient precision1.21 [0.94, 1.55]0%2 studies42,510351not evaluable unclearpptx
Persistent pulmonary hypertensionno data--0 studypptx
Low Apgar score (< 7) (at 1 min)no data0.47 [0.04, 5.45]-1 study335not evaluable NApptx
Neonatal hypotensionno data1.52 [0.06, 37.69]-1 study1143not evaluable NApptx
Neonatal tachypneano data1.27 [0.24, 6.70]-1 study7143not evaluable NApptx

Intrauterine deaths
Adverse outcome PastilleOR 95%CII2k No. casesNo. exposedpublication biasROB???
Late intrauterine deaths (> 22 weeks)insufficient precision1.11 [0.60, 2.05]0%4 studies6793,424not evaluable unclearpptx
Early intrauterine death (< 22 weeks)no evidence of harm0.40 [0.32, 0.50]0%3 studies6423,095not evaluable unclearpptx
Ectopic pregnancyinsufficient precision1.82 [0.37, 8.83]-1 study91,070not evaluable unclearpptx
Elective termination of pregnancyinsufficient precision1.10 [0.71, 1.70]-1 study861,070not evaluable unclearpptx
Therapeutic terminations of pregnancyno data5.06 [0.24, 106.12]-1 study2176not evaluable unclearpptx
Intrauterine deaths (as a whole)no data0.28 [0.01, 6.96]-1 study1100not evaluable NApptx

Neuro-developmental disorders
Adverse outcome PastilleOR 95%CII2k No. casesNo. exposedpublication biasROB???
Neuro-developmental disorders (as a whole)no data1.34 [0.82, 2.17]-1 study138213not evaluable unclearpptx

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