Ondansetron

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Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROB
All congenital malformations (majors, minors, majors and minors, or unspecified)1.04 [0.96, 1.12]43%8 studies167,592116,161not evaluable unclear
Cleft lip with or without cleft palate1.03 [0.88, 1.21]0%7 studies4,58592,238not evaluable unclear
Congenital heart defects1.13 [0.96, 1.33]66%6 studies59,616116,155not evaluable unclear
Major congenital malformations1.02 [0.99, 1.05]0%7 studies150,947115,320not evaluable unclear
Ventricular septal defect1.13 [0.99, 1.27]25%7 studies19,11096,086not evaluable unclear
Cleft palate1.26 [0.87, 1.82]65%6 studies3,36391,261not evaluable unclear
Atrial septal defect1.05 [0.79, 1.39]84%5 studies5,71591,265not evaluable unclear
Hypospadias0.90 [0.70, 1.15]0%5 studies3,3231,874not evaluable unclear
Oro-facial clefts1.20 [1.02, 1.40]0%4 studies3,506113,549not evaluable unclear
Atrioventricular septal defect1.38 [0.65, 2.93]73%4 studies6,19090,765not evaluable unclear
Club foot / Talipes equinovarus1.09 [0.83, 1.44]0%4 studies1,0612,714not evaluable unclear
Limb defects1.02 [0.92, 1.11]0%4 studies8,42590,330not evaluable unclear
Ano-rectal atresia and stenosis0.79 [0.49, 1.27]0%3 studies6711,881not evaluable unclear
Atresia or stenosis of other parts of small intestine0.97 [0.61, 1.53]0%3 studies3941,880not evaluable unclear
Coarctation of aorta0.95 [0.69, 1.29]0%3 studies8441,903not evaluable unclear
Craniosynostosis1.13 [0.95, 1.35]0%3 studies12,7652,512not evaluable unclear
Diaphragmatic hernia1.70 [1.17, 2.48]0%3 studies8752,394not evaluable unclear
Gastroschisis0.89 [0.61, 1.29]0%3 studies9591,894not evaluable unclear
Hypoplastic left heart1.49 [1.03, 2.17]0%3 studies8381,539not evaluable unclear
Pulmonary valve stenosis1.08 [0.79, 1.48]0%3 studies1,0251,913not evaluable unclear
Severe congenital heart defect0.76 [0.63, 0.93]0%2 studies1,88088,851not evaluable unclear
Single ventricle0.90 [0.34, 2.37]71%2 studies42488,706not evaluable unclear
Total anomalous pulm venous return0.84 [0.55, 1.30]0%2 studies50288,705not evaluable unclear
Abdominal wall defects0.98 [0.90, 1.07]0%2 studies8,81689,679not evaluable unclear
Bilateral renal agenesis including Potter syndrome1.85 [1.13, 3.02]0%2 studies1611,630not evaluable unclear
Cardiac septal defects1.57 [1.17, 2.12]43%2 studies39,4752,528not evaluable unclear
Congenital cataract0.94 [0.46, 1.91]0%2 studies2111,494not evaluable unclear
Digestive system anomalies0.93 [0.85, 1.02]0%2 studies9,59889,700not evaluable unclear
Eye defects0.95 [0.69, 1.30]0%2 studies77289,700not evaluable unclear
Genital anomalies1.06 [0.97, 1.17]0%2 studies7,10089,679not evaluable unclear
Limb reduction defects1.01 [0.39, 2.58]0%2 studies5632,115not evaluable unclear
Nervous system anomalies0.94 [0.81, 1.09]0%2 studies3,49689,679not evaluable unclear
Oesophageal atresia with or without tracheo-oesophageal fistula0.71 [0.40, 1.28]0%2 studies3641,496not evaluable unclear
Respiratory system anomalies1.13 [1.01, 1.27]0%2 studies3,95189,679not evaluable unclear
Spina bifida1.24 [0.83, 1.83]0%2 studies461620not evaluable unclear
Transposition of the great vessels0.80 [0.52, 1.23]0%2 studies584649not evaluable unclear
Urinary malformations1.24 [0.76, 2.01]0%2 studies17689,679not evaluable unclear
Ear malformations1.67 [1.17, 2.38]-1 study45088,446not evaluable unclear
25 non statistically significant endpoints reported in only one study

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROB
Preterm (< 37 weeks)1.28 [0.76, 2.15]79%4 studies8,5763,213not evaluable unclear
Low birth weight (< 2500g)1.04 [0.61, 1.77]50%3 studies7,4512,147not evaluable unclear
Small for gestational age (weight)0.96 [0.69, 1.35]67%2 studies50,6642,047not evaluable unclear

Maternal consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROB
Caesarean1.63 [1.28, 2.07]0%2 studies31,113339not evaluable unclear
2 non statistically significant endpoints reported in only one study

Neonatal disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROB
Low Apgar score (< 7) (at 5 min)1.89 [0.62, 5.75]0%2 studies56735not evaluable unclear
Neonatal medical care1.21 [0.94, 1.55]0%2 studies42,510351not evaluable unclear
Persistent pulmonary hypertension--0 study
3 non statistically significant endpoints reported in only one study

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROB
Late intrauterine deaths (> 22 weeks)1.11 [0.60, 2.05]0%4 studies6793,424not evaluable unclear
Early intrauterine death (< 22 weeks)0.40 [0.32, 0.50]0%3 studies6423,095not evaluable unclear
4 non statistically significant endpoints reported in only one study

Neuro-developmental disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROB
1 non statistically significant endpoints reported in only one study