Ondansetron

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Congenital malformations
Adverse outcome PastilleOR 95%CII2k No. casesNo. exposedpublication biasROB???
Abdominal wall defectsno evidence of harm0.98 [0.90, 1.07]0%2 studies8,81689,679not evaluable unclearpptx
All congenital malformations (majors, minors, majors and minors, or unspecified)no evidence of harm1.04 [0.96, 1.12]43%8 studies167,592116,161not evaluable unclearpptx
Ano-rectal atresia and stenosisinsufficient precision0.79 [0.49, 1.27]0%3 studies6711,881not evaluable unclearpptx
Atresia or stenosis of other parts of small intestineinsufficient precision0.97 [0.61, 1.53]0%3 studies3941,880not evaluable unclearpptx
Atrial septal defectinsufficient precision1.05 [0.79, 1.39]84%5 studies5,71591,265not evaluable unclearpptx
Atrioventricular septal defectinsufficient precision1.38 [0.65, 2.93]73%4 studies6,19090,765not evaluable unclearpptx
Bilateral renal agenesis including Potter syndromeharm, strong evidence1.85 [1.13, 3.02]0%2 studies1611,630not evaluable unclearpptx
Cardiac septal defectsharm, strong evidence1.57 [1.17, 2.12]43%2 studies39,4752,528not evaluable unclearpptx
Cleft lip with or without cleft palateno evidence of harm1.03 [0.88, 1.21]0%7 studies4,58592,238not evaluable unclearpptx
Cleft palateinsufficient precision1.26 [0.87, 1.82]65%6 studies3,36391,261not evaluable unclearpptx
Club foot / Talipes equinovarusinsufficient precision1.09 [0.83, 1.44]0%4 studies1,0612,714not evaluable unclearpptx
Coarctation of aortainsufficient precision0.95 [0.69, 1.29]0%3 studies8441,903not evaluable unclearpptx
Congenital cataractinsufficient precision0.94 [0.46, 1.91]0%2 studies2111,494not evaluable unclearpptx
Congenital heart defectsinsufficient precision1.13 [0.96, 1.33]66%6 studies59,616116,155not evaluable unclearpptx
Craniosynostosisinsufficient precision1.13 [0.95, 1.35]0%3 studies12,7652,512not evaluable unclearpptx
Diaphragmatic herniaharm, strong evidence1.70 [1.17, 2.48]0%3 studies8752,394not evaluable unclearpptx
Digestive system anomaliesno evidence of harm0.93 [0.85, 1.02]0%2 studies9,59889,700not evaluable unclearpptx
Ear malformationssignal1.67 [1.17, 2.38]-1 study45088,446not evaluable unclearpptx
Eye defectsinsufficient precision0.95 [0.69, 1.30]0%2 studies77289,700not evaluable unclearpptx
Gastroschisisinsufficient precision0.89 [0.61, 1.29]0%3 studies9591,894not evaluable unclearpptx
Genital anomaliesno evidence of harm1.06 [0.97, 1.17]0%2 studies7,10089,679not evaluable unclearpptx
Hypoplastic left heartharm, strong evidence1.49 [1.03, 2.17]0%3 studies8381,539not evaluable unclearpptx
Hypospadiasno evidence of harm0.90 [0.70, 1.15]0%5 studies3,3231,874not evaluable unclearpptx
Limb defectsno evidence of harm1.02 [0.92, 1.11]0%4 studies8,42590,330not evaluable unclearpptx
Limb reduction defectsinsufficient precision1.01 [0.39, 2.58]0%2 studies5632,115not evaluable unclearpptx
Major congenital malformationsno evidence of harm1.02 [0.99, 1.05]0%7 studies150,947115,320not evaluable unclearpptx
Nervous system anomaliesno evidence of harm0.94 [0.81, 1.09]0%2 studies3,49689,679not evaluable unclearpptx
Oesophageal atresia with or without tracheo-oesophageal fistulainsufficient precision0.71 [0.40, 1.28]0%2 studies3641,496not evaluable unclearpptx
Oro-facial cleftsharm, strong evidence1.20 [1.02, 1.40]0%4 studies3,506113,549not evaluable unclearpptx
Pulmonary valve stenosisinsufficient precision1.08 [0.79, 1.48]0%3 studies1,0251,913not evaluable unclearpptx
Respiratory system anomaliesharm, strong evidence1.13 [1.01, 1.27]0%2 studies3,95189,679not evaluable unclearpptx
Severe congenital heart defectno evidence of harm0.76 [0.63, 0.93]0%2 studies1,88088,851not evaluable unclearpptx
Single ventricleinsufficient precision0.90 [0.34, 2.37]71%2 studies42488,706not evaluable unclearpptx
Spina bifidainsufficient precision1.24 [0.83, 1.83]0%2 studies461620not evaluable unclearpptx
Total anomalous pulm venous returninsufficient precision0.84 [0.55, 1.30]0%2 studies50288,705not evaluable unclearpptx
Transposition of the great vesselsno evidence of harm0.80 [0.52, 1.23]0%2 studies584649not evaluable unclearpptx
Urinary malformationsinsufficient precision1.24 [0.76, 2.01]0%2 studies17689,679not evaluable unclearpptx
Ventricular septal defectinsufficient precision1.13 [0.99, 1.27]25%7 studies19,11096,086not evaluable unclearpptx
25 non statistically significant endpoints reported in only one study

Growth parameters and prematurity
Adverse outcome PastilleOR 95%CII2k No. casesNo. exposedpublication biasROB???
Low birth weight (< 2500g)insufficient precision1.04 [0.61, 1.77]50%3 studies7,4512,147not evaluable unclearpptx
Preterm (< 37 weeks)insufficient precision1.28 [0.76, 2.15]79%4 studies8,5763,213not evaluable unclearpptx
Small for gestational age (weight)insufficient precision0.96 [0.69, 1.35]67%2 studies50,6642,047not evaluable unclearpptx

Maternal consequences
Adverse outcome PastilleOR 95%CII2k No. casesNo. exposedpublication biasROB???
Caesareanharm, strong evidence1.63 [1.28, 2.07]0%2 studies31,113339not evaluable unclearpptx
2 non statistically significant endpoints reported in only one study

Neonatal disorders
Adverse outcome PastilleOR 95%CII2k No. casesNo. exposedpublication biasROB???
Low Apgar score (< 7) (at 5 min)no data1.89 [0.62, 5.75]0%2 studies56735not evaluable unclearpptx
Neonatal medical careinsufficient precision1.21 [0.94, 1.55]0%2 studies42,510351not evaluable unclearpptx
Persistent pulmonary hypertensionno data--0 studypptx
3 non statistically significant endpoints reported in only one study

Intrauterine deaths
Adverse outcome PastilleOR 95%CII2k No. casesNo. exposedpublication biasROB???
Early intrauterine death (< 22 weeks)no evidence of harm0.40 [0.32, 0.50]0%3 studies6423,095not evaluable unclearpptx
Late intrauterine deaths (> 22 weeks)insufficient precision1.11 [0.60, 2.05]0%4 studies6793,424not evaluable unclearpptx
4 non statistically significant endpoints reported in only one study

Neuro-developmental disorders
Adverse outcome PastilleOR 95%CII2k No. casesNo. exposedpublication biasROB???
1 non statistically significant endpoints reported in only one study