Rizatriptan

Exposed non-exposed studies (cohort)

Study Country
Study period
Population source Exposure definition Non-exposure definition Sample size Rmk
Källén (control exposed to ergots), 2011 Sweden
1995 - 2008
All deliveries in Sweden (1 211 670 women) recorded in the Medical Birth Register with data from antenatal care. Infants born to women who had used Rizatriptan during pregnancy. (This is a subgroup of exposure among the whole exposed group considered in the study). exposed to other treatment, sick
Infants born to women who had used Ergots drugs for migraine during pregnancy. (This is a subgroup of exposure among the whole exposed group considered in the study).
157 / 527 Exposed groups of the whole study: drugs for migraine (ergots or triptans).
Källén (control unexposed, disease free), 2011 Sweden
1995 - 2008
All deliveries in Sweden (1 211 670 women) recorded in the Medical Birth Register with data from antenatal care. Infants born to women who had used drugs for migraine (triptans or ergots) during pregnancy. Exposure to Rizatriptan provided and considered as a separate subgroup. unexposed, disease free
Infants born to women who did not use drugs for migraine.
157 / 1229901 Exposed groups of the whole study: drugs for migraine (ergots or triptans). 1229901= Total number of infants (n=1233228) - Number of infants whose mother used drugs for migraine in 1st trimester (n=3327)
Nezvalová-Henriksen (Control unexposed, disease free), 2013 Norway
2004 - 2007
All singleton deliveries (after the 12th gestational week) without chromosomal abnormalities during the study period. Rizatriptan prescription redemption during pregnancy ('anytime' or 'during the first trimester' or 'during the second trimester' or 'during the third trimester'). (This is a subgroup of exposure among the whole exposed group considered in the study). unexposed, disease free
Pregnant women did not redeem triptans during the study period (the population comparison group).
334 / 178565 Other triptans also studied.
Nezvalová-Henriksen (Control unexposed, sick), 2013 Norway
2004 - 2007
All singleton deliveries (after the 12th gestational week) without chromosomal abnormalities during the study period. Rizatriptan prescription redemption during pregnancy ('anytime' or 'during the first trimester' or 'during the second trimester' or 'during the third trimester'). (This is a subgroup of exposure among the whole exposed group considered in the study). unexposed, sick
Triptan prescription redemption between 7 and 1 month prior to pregnancy only.
334 / 1095 Other triptans also studied.

Case-control studies (cohort)

Study Country
Study period
Case Control Sample size Rmk

See the method used to produce these results