demonstrated suggested inconclusive safety concern ongoing study display ongoing demontrated benefit only observational study
COVID-19 prophylaxis (excluding children)
potential COVID-19 treatments
anti-inflammatoty and immuno-therapy
anti-inflammatory therapies
colchicine Gendelman
non-steroidal anti-inflammatory drugs Chandan
Immunostimulants drugs
neutralizing antibody
bamlanivimab monotherapy BLAZE-2 US ...
casirivimab/imdevimab (Ronapreve) Cov-2069 ...
cilgavimab and tixagevimab (Evusheld) PROVENT Jurdi
antiviral and associated therapy
bromhexine Mikhaylov
chloroquine and derivatives
hydroxychloroquine COVID-PEP-Post exposure ... Rojas-Serrano Barnabas RV COVID PREP ... HERO-HCQ ... Raja Bhattacharya EPI-PHARE BCN PEP-CoV-2-Study 1 ... Rentsch Grau-Pujol COVID PREP HCQ ... PATCH-cohort 3 PreP ... Abella Gendelman Jung Syed EPICOS ... Seet ...
ivermectin NCT04422561 ... Alam Behera Ivercar-Tuc Behera Seet 2021
nirmatrelvir / ritonavir (Paxlovid) EPIC PEP
Drugs for acid related disorders
H2 blockers Almario ...
proton pump inhibitors (PPI) Almario ... Lee ... Almario ... McKeigue ... Ullah ... Blanc
miscellaneous
mouthrise and gargling agents
mouthrinses Carrouel
povidone-iodine Seet ...
Renin-angiotensin-system-acting agents Mancia Reynolds ... Khera ... Khera ... Morales
vaccines Shah Waissengrin Pawlowski Andrejko Yair Boyarsky Pawlowski Public Health England ... Haberman Scotland delta ... Harris Butt Canada ... Public Health England, May 16, 2021 ... REACT-SCOT Martinez-Baz REACT-1 round 13 final report ... CDC Mesa County, Colorado Oxford ... HEROES-RECOVER ... Grannis VA ... Sultan Reynolds Ostropolets Li X UKHSA report week 12 ...
A EFFACER_sequential Immunization NCT04833101
BCG vaccination NCT04648800 Tsilika
complete primary vaccine series South Africa ...
CoVLP (MT-2766, Medicago) Hager ...
first booster dose Pfizer/BioNTech Booster study Bar-On Arbel Sisonke 2 ... Barda Patalon Mattiuzzi England ... Ontario ... COVI3 Kislaya Tenforde Tenforde McConeghy Accorsi Patalon Abu-Raddad C4591031- first boost C4591031- first boost
mRNA vaccine (any) - first boost Tan
Comirnaty - first boost C4591031- first boost C4591031- first boost
heterologous prime-boost CombiVacS Hillus
Inactivated virus vaccine Li
CoronaVac (SinoVac) DOUBLON SinoVac-PROFISCOV phase 3 Zhang PROFISCOV ... Wu Sinovac Turkish Trial Hitchings Faria Chile study ... Bonfa Wan
Covaxin, Bharat Biotech (BBV152) Ella
Sinopharm Beijing (BBIBP-CorV) Xia ... Sultan Kanokudom Ashmawy Rearte
Sinopharm Wuhan Sinopharm Wuhan Vero cell Xia ...
mRNA vaccine CoVEHPI ... Thompson Tande Boyarsky Agur Aleman Chung Mayo Clinic ... Qatar ... Nakahara Tenforde Tenforde Shibli McConeghy EPIPHAR ... Thompson -VISIOn Network ... Thompson -VISIOn Network ... Accorsi Abu-Raddad Lauring Shemer McMurry Kirsebom ... Fraiman
Comirnaty (tozinameran - Pfizer/BIONTECH) BNT162b2 phase 3 ... Chodcik Dagan SIREN ... Scotland cohort Amit Weekes Yanay Pawlowski Goldberg Zadok Bernal ... Palich Rozen-Zvi Haas Abu-Raddad Angel Haas Heymann Bjork Wan Tenforde Nanduri Barda Klein EPI-PHARE South Africa ... England ... Sultan Coggiola Watanabe xie Lustig Shibli Nguyen Simpson ... Husby ... Kanokudom Patalon Shemer Patone Shasha Tartof
Spikevax (Moderna mRNA-1273 COVID-19 vaccine) COVE Moderna/NIH phase 3 ... Moderna study 201 100µg Benotmane Pawlowski Klein Husby ... Southern California ... Southern California ...
Non replicating viral vector Pitisuttithum
CanSino (Convidecia) CanSino phase 3 CanSino phase 2 ... Fengcai Li J NCT04540419
Covishield (Oxford/AZ formulation) Kulkarni
Janssen AD26 vaccine (JNJ-78436735) Sadoff ENSEMBLE ... HORIZON 1 Pawlowski Sisonke 2 ... MixNMatch Study Reindl-Schwaighofer EPIPHARE ... Husby ... Botton ... Sisonke study ...
Sputnik V (Gam-COVID-Vac) RESIST ... Rearte Nabirova
Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) AstraZeneca phase 3 US ... Folegatti ChAdOx1 phase 3 ... COV005 Scotland cohort Bernal ... Pottegard John Bernal Com-COV Edward ... Burn ... ComFluCOV ... Sultan Bonelli Com-COV2 Asano Nguyen Hippisley-Cox Simpson ... EPIPHARE ... AstraZeneca Oxford pooled analysis ... Husby ... Kanokudom Clemens Patone Rearte AstraZeneca phase 3 US ... Valim
protein subunit vaccine Chappell Meng Shu Shinkai Liu
Nuvaxovid (NVX-CoV2373) Novavax Novavax phase 3 UK ... Keech Novavax PREVEND-19 phase 3 US ... Novavax phase 2 South Africa ...
Replicating Viral Vector Vanhoutte
seasonal influenza vaccines ComFluCOV ...
second booster dose Bar-On Regev-Yochay ... Regev-Yochay ... Arbel / Magen
mRNA vaccine (any) - second boost
Comirnaty - second boost Regev-Yochay ... Cohen
Spikevax - second boost Regev-Yochay ...
Vitamins
vitamin C Bengu

12 studies excluded by filtering options 2

5347 Mehra, 2020 2124excludednot a RCThigh risk of bias
5521 Del Amo, 2020 200excludedrisk of bias not avaialble
7070 PHE variants (Technical briefing 12 22 may 2021), 2021 2202excludednot a RCT
7420 PHE (Stowe), 2021 2133excludednot a RCThigh risk of bias
8149 PHE Technical briefing 16 (11/18 June 2021), 2021 2133excludednot a RCThigh risk of bias
8275 Musser, 2021 2130excludednot a RCTrisk of bias not avaialble
8350 Rosenberg, 2021 2130excludednot a RCTrisk of bias not avaialble
8515 Scobie, 2021 2200excludednot a RCTrisk of bias not avaialble
9170 UKHSA report 33 (23 december 2021), 2021 2200excludednot a RCTrisk of bias not avaialble
9176 UKHSA 31 december 2021, 2021 2200excludednot a RCTrisk of bias not avaialble
9214 Southern California (Lewnard), 2022 2130excludednot a RCTrisk of bias not avaialble
9294 UKHSA (report W4- 27 January), 2022 2120excludednot a RCTrisk of bias not avaialble