table network network 2
demonstrated suggested inconclusive safety concern ongoing study display ongoing demontrated benefit only
COVID 19 hospitalized
COVID-19 severe or critically
potential COVID-19 treatments
adjuvant therapies
anticoagulant
anticoagulant, curative dose REMAP-CAP, ACTIV-4a, ATTACC ... COVID-PACT
anticoagulation, intermediate prophylactic dose INSPIRATION
heparin at therapeutic dose ATTACC ... ACTIV-4a ... REMAP-CAP Anticoagulation
anti-inflammatoty and immuno-therapy
anti-inflammatory therapies
colchicine COLCHIVID
stem cells Shu Shi
vilobelimab (IFX-1) PANAMO
corticosteroids
dexamethasone DEXA-COVID19 CODEX ... Jamaati Rashad Naik
Dexamethasone 12mg COVID STEROID 2
Hydrocortisone CAPE-COVID REMAP-CAP, fixed 7-day course REMAP-CAP, shock-dependent course Munch ...
methylprednisolone Steroids-SARI Edalatifard Farahani
Immunostimulants drugs
convalescent plasma treatment CP-COVID-19 ILBS-COVID-02 ... Li Rasheed O’Donnell PlasmAr CAPSID AlQahtani REMAP-CAP ... RECOVER PICP19 ... Pouladzadeh Sekine ... Ray
immunoglobulin therapy Tabarsi Gharebaghi Raman
interferon
IFN beta-1a Davoudi-Monfared Darazam ... Kalil ...
IFN beta-1b Rahmani Darazam ...
neutralizing antibody
equine polyclonal antibodies INM005 Lopardo
Immunosuppressants drugs
abatacept ACTIV-1 abatacept
adalimumab Fakharian
anti-interleukin-6
Levilimab V.Lomakin ...
sarilumab sarilumab Sanofi phase 3 US sarilumab Sanofi phase 3 outside US REMAP-CAP sarilumab
sarilumab high dose (400mg) Lescure ...
sarilumab low dose (200mg) Lescure ...
tocilizumab MARIPOSA COVACTA ... CORIMUNO-TOCI-1 ... REMAP-CAP ... Veiga Rashad Talaschian Hamed CORIMUNO-TOCI-ICU ... NCT04377750 ... Rosas ... Sarhan Sarhan
canakinumab CAN-COVID
cenicriviroc ACTIV-1 cenicriviroc
infliximab ACTIV-1 infliximab
itolizumab Kumar
janus kinase (JAK) inhibitor
baricitinib COV-BARRIER ...
ruxolitinib Cao DEVENT
TD-0903
TD-0903 10mg Singh ...
TD-0903 1mg Singh ...
TD-0903 3mg Singh ...
tacrolimus TACROVID
thalidomide Amra
Kinase inhibitors
imatinib Aman
statins
Atorvastatin INSPIRATION-S
antiviral and associated therapy
azithromycin COALITION II Covid-19 Brazil ...
chloroquine and derivatives
hydroxychloroquine REMAP-CAP-HCQ HYDRA ... Sarhan Sarhan
ivermectin Okumuş Galan Galan
lopinavir/ritonavir Cao REMAP-CAP ...
Lopinavir/ritonavir plus hydroxychloroquine REMAP-CAP ...
remdesivir CAP-China ...
miscellaneous
alpha lipoic acid Ming Zhong
aviptadil ACTIV-3 Critical Care
pyridostigmine Fragoso-Saavedra ...
Oral antidiabetic drugs
DPP-4 inhibitor Abuhasira
Vitamins
vitamin C Zhang Jamali Moghadam Siahkali Kumari
Vitamin D COVID-VIT-D

60 studies excluded by filtering options 1

5092 Yang, 2020 1133not a RCThigh risk of bias
5228 Bean, 2020 1193not a RCThigh risk of bias
5295 Zhang, 2020 1133not a RCThigh risk of bias
5331 Li, 2020 1134not a RCThigh risk of bias
5332 Meng, 2020 1134not a RCThigh risk of bias
5345 Yan et al., 2020 1204not a RCThigh risk of bias
5346 Mancia, 2020 1203not a RCThigh risk of bias
5347 Mehra, 2020 2124excludednot a RCThigh risk of bias
5348 Reynolds (COVID positive patient), 2020 1133not a RCThigh risk of bias
5349 Reynolds (prophylaxis), 2020 1133not a RCThigh risk of bias
5370 Khera (outpatients), 2020 1133not a RCThigh risk of bias
5372 Khera (inpatients), 2020 1133not a RCThigh risk of bias
5399 Northwell Consortium (Richardson), 2020 0990selection pending
5440 Morales, 2020 1130not a RCTrisk of bias not avaialble
5604 Schneeweiss, 0 0130selection pending
5605 Vila-Corcole, 0 0130selection pending
5619 Pan, 2020 0130selection pending
5797 Rossi, 0 0130selection pending
5903 Anzola, 2020 0100selection pending
6660 Bae, 2021 0120selection pending
6729 Shah, 2021 1133not a RCThigh risk of bias
6788 Waissengrin, 2021 0130selection pending
6790 Pawlowski, 2021 1130not a RCTrisk of bias not avaialble
6894 Andrejko, 2021 1200not a RCTrisk of bias not avaialble
6927 Rossman, 2021 0130selection pending
6931 Yair, 2921 1320not a RCTrisk of bias not avaialble
6934 Boyarsky, 2021 1320not a RCTrisk of bias not avaialble
6949 Pawlowski, 2021 1130not a RCTrisk of bias not avaialble
6981 Public Health England (Harris), 2021 1133not a RCThigh risk of bias
7025 Haberman, 2021 0130selection pending
7070 PHE variants (Technical briefing 12 22 may 2021), 2021 2202excludednot a RCT
7325 Skowronski, 2021 0130selection pending
7419 Scotland delta (Sheikh), 2021 1203not a RCThigh risk of bias
7420 PHE (Stowe), 2021 2133excludednot a RCThigh risk of bias
7950 Harris, 2021 1133not a RCThigh risk of bias
8143 Butt, 2021 1202not a RCT
8147 Canada (Nasreen), 2021 1202not a RCT
8149 PHE Technical briefing 16 (11/18 June 2021), 2021 2133excludednot a RCThigh risk of bias
8150 Ramasamy, 2021 0320selection pending
8164 Public Health England, May 16, 2021 (Bernal), 2021 1202not a RCT
8255 REACT-SCOT, 2021 1200not a RCTrisk of bias not avaialble
8272 Martinez-Baz, 2021 1130not a RCTrisk of bias not avaialble
8274 REACT-1 round 13 final report (Elliott, Imperial College London), 2021 1133not a RCThigh risk of bias
8275 Musser, 2021 2130excludednot a RCTrisk of bias not avaialble
8294 CDC Mesa County, Colorado, 2021 1133not a RCThigh risk of bias
8313 Bahl (Fully vaccinated vs unvaccinated), 2021 0100selection pending
8350 Rosenberg, 2021 2130excludednot a RCTrisk of bias not avaialble
8359 Oxford (Pouwels), 2021 1132not a RCT
8360 HEROES-RECOVER (Fowlkes), 2021 1133not a RCThigh risk of bias
8513 Grannis, 2021 1203not a RCThigh risk of bias
8514 VA (Bajema), 2021 1203not a RCThigh risk of bias
8515 Scobie, 2021 2200excludednot a RCTrisk of bias not avaialble
9170 UKHSA report 33 (23 december 2021), 2021 2200excludednot a RCTrisk of bias not avaialble
9176 UKHSA 31 december 2021, 2021 2200excludednot a RCTrisk of bias not avaialble
9214 Southern California (Lewnard), 2022 2130excludednot a RCTrisk of bias not avaialble
9216 Sultan, 2022 0120selection pending
9267 Ostropolets, 2021 0120selection pending
9294 UKHSA (report W4- 27 January), 2022 2120excludednot a RCTrisk of bias not avaialble
9491 Li X, 2022 1120not a RCTrisk of bias not avaialble
9590 UKHSA report week 12 (24 March 2022), 2022 1120not a RCTrisk of bias not avaialble

 

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