demonstrated suggested inconclusive safety concern ongoing study display ongoing demontrated benefit only
COVID 19 hospitalized
COVID 19 hospitalizedCOVID 19 all comersCOVID-19 mild to moderateCOVID-19 severe or critically
anti-inflammatoty and immuno-therapy
anti-inflammatory therapies
anti GM-CSF
mavrilimumab MASH-COVID ...
clarithromycine Rashad ...
colchicine COLCOVID Lopes MIF Salehzadeh GRECCO-19 RECOVERY ... Horby COL-COVID ... COLCHIVID
Colchicine plus rosuvastatin COLSTAT Gaitan-Duarte ...
non-steroidal anti-inflammatory drugs Guzman-Esquivel
Indomethacin Ravichandran
stem cells Lanzoni Carmenate ... Shu Shi
vilobelimab (IFX-1) PANAMO
corticosteroids GLUCOCOVID
dexamethasone RECOVERY dexamethasone DEXA-COVID19 CODEX ... Jamaati Rashad Naik
Dexamethasone 12mg COVID STEROID 2
Hydrocortisone CAPE-COVID REMAP-CAP, fixed 7-day course REMAP-CAP, shock-dependent course Munch ...
methylprednisolone Tang X Metcovid Ranjbar Steroids-SARI Edalatifard Farahani
Immunostimulants drugs
convalescent plasma treatment ConCOVID ... ConPlas-19 COP-COVID-19 CONTAIN COVID-19 PC/COVID-19 NCT04397757 PLACO-COVID CONCOR-1 CPC-SARS NCT04442191 DAWN-Plasma NCT04385199 COPLA-II trial NCT04403477 ... ASCOT RECOVERY ... CONFIDENT PERUCONPLASMA Bennett-Guerrero Salman Kirenga LACCPT Co-CLARITY NCT04528368 Holm K CCAP-2 Baldeon Menichetti LIFESAVER PLACID Libster CP-COVID-19 ILBS-COVID-02 ... Li Rasheed O’Donnell PlasmAr CAPSID AlQahtani REMAP-CAP ... RECOVER PICP19 ... Pouladzadeh Sekine ... Ray
Early convalescent plasma. Balcells
immunoglobulin therapy Sakoulas Parikh Tabarsi Gharebaghi Raman
interferon
IFN beta-1a SOLIDARITY ... Davoudi-Monfared Darazam ... Kalil ...
high-dose IFN beta-1a Darazam
IFN beta-1b Rahmani Darazam ...
IFN gamma Esquivel-Moynelo
inhaled interferon
IFN alpha
pegylated interferon-α2b Pandit Shashi Bhushan
recombinant super-compound interferon rSIFN-co Li
SNG001 inhaled interferon beta Synairgen SG016 SPRINTER
interferon / TFF2 Fu
peginterferon Jagannathan
PNB001 Lattmann
neutralizing antibody ITAC
amubarvimab/romlusevimab (BRII-196 and BRII-198-Brii Biosciences) ACTIV-3 ...
bamlanivimab monotherapy ACTIV-3/TICO LY-CoV555
casirivimab/imdevimab (Ronapreve) RECOVERY ... Somersan-Karakaya ...
cilgavimab and tixagevimab (Evusheld) ACTIV-3/TICO ...
equine polyclonal antibodies INM005 Lopardo
sotrovimab (Xevudy; VIR-7831) ACTIV-3/ TICO ...
Immunosuppressants drugs
abatacept ACTIV-1 abatacept
adalimumab Fakharian
anakinra SAVE-MORE CORIMUNO-ANA-1
anti-interleukin-6
Levilimab V.Lomakin ...
sarilumab CORIMUNO-SARI-1 ... sarilumab Sanofi phase 3 US sarilumab Sanofi phase 3 outside US REMAP-CAP sarilumab
sarilumab high dose (400mg) sarilumab phase 2 high dose Lescure ...
sarilumab low dose (200mg) sarimulab phase 2 low dose Lescure ...
tocilizumab Dongsheng Wang RCT-TCZ-COVID-19 EMPACTA RECOVERY Soin AS ... Rutgers NCT04412772 ... Declercq J ... NCT04577534 ... EU-CTR2020-001375-32 ... EU-CTR2020-001748-24 ... NCT04479358 ... NCT04434717 ... TOCOVID BACC Bay Tocilizumab Trial MARIPOSA COVACTA ... CORIMUNO-TOCI-1 ... REMAP-CAP ... Veiga Rashad Talaschian Hamed CORIMUNO-TOCI-ICU ... NCT04377750 ... Rosas ... Sarhan Sarhan
canakinumab Sheng ... CAN-COVID
cenicriviroc ACTIV-1 cenicriviroc
infliximab ACTIV-1 infliximab
itolizumab Kumar
janus kinase (JAK) inhibitor
baricitinib COV-BARRIER ACTT-2 ... RECOVERY COV-BARRIER ...
ruxolitinib Cao DEVENT
TD-0903
TD-0903 10mg Singh ...
TD-0903 1mg Singh ...
TD-0903 3mg Singh ...
tofacitinib STOP-COVID ... Murugesan
lenzilumab LIVE-AIR ...
tacrolimus TACROVID
thalidomide Amra
Kinase inhibitors
acalabrutinib CALAVI CALAVI US
imatinib Covid-19 HUF Aman
leflunomide Wang et al. Wang
statins
Atorvastatin INSPIRATION-S

25 studies excluded by filtering options 1

4930 Huijie Bian, 2020 2313excludednot a RCThigh risk of bias
5317 Lu, 2020 1223not a RCThigh risk of bias
5319 Wu, 2020 1133not a RCThigh risk of bias
5453 Raef, 2020 1134not a RCThigh risk of bias
5454 Jianfeng, 2020 1133not a RCThigh risk of bias
5455 Tomasz, 2020 1204not a RCThigh risk of bias
5456 Fernández Cruz, 2020 1133not a RCThigh risk of bias
5476 Yuan, 2020 0130selection pending
5484 Salton (Methylprednisolone), 2020 0134selection pending
5485 openSafely, 2020 0130selection pending
5510 Malgorzata, 2020 1134not a RCThigh risk of bias
5552 Rahman, 2020 0130selection pending
5568 Zhang, 2020 0130selection pending
5603 Albani, 2020 0130selection pending
5612 Bernaola, 2020 2130excludednot a RCTrisk of bias not avaialble
5614 Monreal, 2020 0130selection pending
5615 Nelson (Methylprednisolone), 2020 0130selection pending
5639 Li (Methylprednisolone, Shanghai cohort), 2020 0130selection pending
5796 SAM-COVID-19, 2020 0130selection pending
5840 Majmundar, 2020 0130selection pending
5939 Li (Methylprednisolone, Validation cohort), 2020 0130selection pending
5952 Rodriguez-Bano (intermediate-high dose CS), 2020 0130selection pending
5953 Rodriguez-Bano (CS pulse dose), 2020 0130selection pending
6036 Esba, 2020 0100selection pending
6048 Wu, 2020 0110selection pending