antiviral and associated therapy living meta-analysis of clinical studies

demonstrated suggested inconclusive safety concern ongoing study display ongoing demontrated benefit only

	COVID 19 hospitalized
	COVID-19 mild to moderate
antiviral and associated therapy
azithromycin	COALITION I Covid-19 Brazil ... Rashad A ...
azvudine	Ren
bromhexine	Li T
chloroquine and derivatives
chloroquine	NCT04342650
hydroxychloroquine	Zhaowei Chen Kamran Coalition Covid-19 Brazil I ... NCT04333654 FACCT Trial HC-nCoV ... Dubee
Ensitrelvir (XOCOVA)	Mukae - Phase 2a
favipiravir	NCT04542694 Holubar M IRCT20151227025726N14 // U07 Ruzhentsova T FACCT Trial Dabbous HM Shinkai Udwadia AVIFAVIR Solaymani-Dodaran Shenoy S
favipiravir plus interferon	Khamis
hydroxychloroquine plus macrolides
azithromycin plus hydroxychloroquine	Coalition Covid-19 Brazil I ...
ivermectin	Bukhari Kirti Abd-Elsalam Babalola Krolewiecki RIVET-COV ... Ahmed Chachar I-TECH ... Chaccour Mayer Shahbaznejad
ivermectin plus doxycycline	NCT04523831 ...
lopinavir/ritonavir	ELACOI ...
lopinavir/ritonavir, ribavirin and interferon beta-1b	Hung et al.
nitazoxanide	Fontanesi Rocco Silva
remdesivir	GS-US-540-5774, 5 days GS-US-540-5773 ... GS-US-540-5774, 10 days
sofosbuvir and ledipasvir	Nourian A
umifenovir (arbidol)	Yethindra ELACOI ...

70 studies excluded by filtering options 1

4861	Cai -FAVIPIRAVIR, 2020	1	31	0		not a RCT	risk of bias not avaialble
4905	ChiCTR2000029975, 0	2	30	0	excluded	not a RCT	risk of bias not avaialble
5209	SIMPLE (Grein), 0	2	30	0	excluded	not a RCT	risk of bias not avaialble
5210	Ye et al., 2020	2	99	0	excluded	not a RCT	risk of bias not avaialble
5288	Barbosa, 2020	2	13	0	excluded	not a RCT	risk of bias not avaialble
5314	Magagnoli (HC AZ), 2020	1	13	3		not a RCT	high risk of bias
5351	Mallat, 2020	2	13	0	excluded	not a RCT	risk of bias not avaialble
5365	Rosenberg, 2020	1	13	3		not a RCT	high risk of bias
5365	Rosenberg, 2020	1	13	3		not a RCT	high risk of bias
5365	Rosenberg, 2020	1	13	3		not a RCT	high risk of bias
5371	Carlucci, 2020	0	13	4	selection pending
5374	Million, 2020	2	30	0	excluded	not a RCT	risk of bias not avaialble
5375	Mehra, 2020	2	13	3	excluded	not a RCT	high risk of bias
5375	Mehra, 2020	2	13	3	excluded	not a RCT	high risk of bias
5416	Guerin, 2020	2	31	4	excluded	not a RCT	high risk of bias
5416	Guerin, 2020	2	31	4	excluded	not a RCT	high risk of bias
5445	Nguyen, 2020	0	21	0	selection pending
5448	COVID-19 Global Rheumatology Alliance, 2020	0	13	0	selection pending
5470	Singh, 2020	0	21	0	selection pending
5471	Sarayani, 2020	0	21	0	selection pending
5482	Sbidian (HCQ plus AZI), 2020	1	13	4		not a RCT	high risk of bias
5490	Kurd, 2020	0	10	0	selection pending
5509	Lagier, 2020	1	13	4		not a RCT	high risk of bias
5513	Arshad (HCQ AZ), 2020	1	13	4		not a RCT	high risk of bias
5546	remdesevir external control, 0	0	13	0	selection pending
5559	Davido, 2020	1	13	4		not a RCT	high risk of bias
5599	Karolyi, 2020	0	13	0	selection pending
5611	Wang, 0	0	13	0	selection pending
5681	Lane, 2020	0	13	0	selection pending
6034	Huang, 2020	0	99	0	selection pending
6047	Hsia, 2020	0	99	0	selection pending
6064	Glorial F, 2020	1	10	0		not a RCT	risk of bias not avaialble
6080	IDEA, 2020	2	10	0	excluded	not a RCT	risk of bias not avaialble
6082	ICON, 2020	0	13	0	selection pending
6095	Camprubi, 2020	1	11	0		not a RCT	risk of bias not avaialble
6098	Patel, 2020	2	10	0	excluded	not a RCT	risk of bias not avaialble
6134	Morgenstern, 2020	2	30	0	excluded	not a RCT	risk of bias not avaialble
6184	Erdem, 2020	2	11	0	excluded	not a RCT	risk of bias not avaialble
6252	NCT04376814-Group A, 2020	0	31	0	selection pending
6262	Yamamura, 2020	2	30	0	excluded	not a RCT	risk of bias not avaialble
6263	Calik, 2020	1	10	4		not a RCT	high risk of bias
6267	Murohashi, 2020	2	10	0	excluded	not a RCT	risk of bias not avaialble
6287	Kocayigit H, 2020	1	10	0		not a RCT	risk of bias not avaialble
6332	Rodriguez-Molinero, 2020	1	10	0		not a RCT	risk of bias not avaialble
6339	Delliere, 2020	2	13	0	excluded	not a RCT	risk of bias not avaialble
6372	Alam, 2020	0	31	3	selection pending
6373	Behera, 2020	1	20	0		not a RCT	risk of bias not avaialble
6374	NCT04425850 (Caravallo), 2020	2	31	0	excluded	not a RCT	risk of bias not avaialble
6375	Cadegiani -Iver, 2020	2	99	0	excluded	not a RCT	risk of bias not avaialble
6379	Chamie-Quintero,, 2020	2	15	0	excluded	not a RCT	risk of bias not avaialble
6381	Espitia-Hernandez, 2020	1	31	0		not a RCT	risk of bias not avaialble
6381	Espitia-Hernandez, 2020	1	31	0		not a RCT	risk of bias not avaialble
6381	Espitia-Hernandez, 2020	1	31	0		not a RCT	risk of bias not avaialble
6381	Espitia-Hernandez, 2020	1	31	0		not a RCT	risk of bias not avaialble
6382	Khan, 2020	0	13	0	selection pending
6382	Khan, 2020	0	13	0	selection pending
6383	Soto-Becerra, 2020	0	12	2	selection pending
6383	Soto-Becerra, 2020	0	12	2	selection pending
6384	Spoorthi, 2020	1	31	0		not a RCT	risk of bias not avaialble
6384	Spoorthi, 2020	1	31	0		not a RCT	risk of bias not avaialble
6384	Spoorthi, 2020	1	31	0		not a RCT	risk of bias not avaialble
6384	Spoorthi, 2020	1	31	0		not a RCT	risk of bias not avaialble
6516	Eslami, 2020	1	31	0		not a RCT	risk of bias not avaialble
6625	Nasir, 2020	2	31	0	excluded	not a RCT	risk of bias not avaialble
6625	Nasir, 2020	2	31	0	excluded	not a RCT	risk of bias not avaialble
6749	Chen_oseltamivir, 2020	1	13	4		not a RCT	high risk of bias
6750	Chen_arbidol, 2020	1	13	4		not a RCT	high risk of bias
6751	Chen_lopi_rito, 2020	1	13	4		not a RCT	high risk of bias
7995	Hazan, 2021	2	32	0	excluded	not a RCT	risk of bias not avaialble
8328	Behera, 2021	0	13	0	selection pending